Research Center Pharmaceutical Engineering (RCPE) (98888)

  • 8010

    Inffeldgasse 13 Graz

    Austria

Research Output 1991 2020

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2016

Comparing particle size distributions of an arbitrary shape

Scheibelhofer, O., Besenhard, M., Piller, M. & Khinast, J., 16 Feb 2016, In : Powder Technology. 294, p. 134-145

Research output: Contribution to journalArticleResearchpeer-review

Continuous feeding of low-dose APIs via periodic micro dosing

Faulhammer, E., Khinast, J. & Fathollahi, S., 17 May 2016, In : International Journal of Pharmaceutics.

Research output: Contribution to journalArticleResearchpeer-review

Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Paudel, A., Llusa, M., Mohr, S., Baumgartner, R., Koscher, G. & Khinast, J., 2 Aug 2016, In : Drug development and industrial pharmacy. p. 1360-1364 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Extrusion
Pharmaceutical Preparations
Feeding Methods
Powders
Suspensions

Defining patient centric pharmaceutical drug product design

Stegemann, S., 1 Apr 2016, In : The AAPS journal . 18, 5, p. 10476-1055

Research output: Contribution to journalArticleResearchpeer-review

Development of a design space and predictive statistical model for capsule filling of low-fill-weight inhalation products

Paudel, A., Faulhammer, E., Llusa, M., Wahl, PR., Lawrence, S., Biserni, S., Calzolari, V. & Khinast, J., 1 Feb 2016, In : Drug development and industrial pharmacy. 42, 2, p. 221-230

Research output: Contribution to journalArticleResearchpeer-review

Statistical Models
Inhalation
Capsules
Powders
Weights and Measures

Dynamic cross-flow filtration: enhanced continuous small-scale solid-liquid separation

Gursch, J., Hohl, R., Dujmovic, D., Brozio, J., Krumme, M., Rasenack, N. & Khinast, J., 2016, In : Drug development and industrial pharmacy. 42, 6, p. 977-984

Research output: Contribution to journalArticleResearchpeer-review

Impact of impeller design on high-shear wet granulation

Börner, M., Michaelis, M., Siegmann, E., Radeke, C. & Schmidt, U., Jul 2016, In : Powder Technology.

Research output: Contribution to journalArticleResearchpeer-review

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Paudel, A., Gomes Lopes, D., Garsuch, V., Becker, K., Zimmer, A. & Salar-Behzadi, S., 20 Aug 2016, In : International Journal of Pharmaceutics. p. 285-295

Research output: Contribution to journalArticleResearchpeer-review

Sorbitol
Ibuprofen
Sodium
Powders
Excipients

Lyophilized protein powders: A review of analytical tools for root cause analysis of lot-to-lot variability

Paudel, A., Wahl, V. & Khinast, J., Sep 2016, In : Trends in Analytical Chemistry. p. 468-491

Research output: Contribution to journalArticleResearchpeer-review

powders
freeze drying
proteins
biopharmaceuticals
process control

Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer

Hohl, R., Scheibelhofer, O., Stocker, E., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Lochmann, D., Sacher, S. & Zimmer, A., 2 Mar 2016, In : AAPS PharmSciTech .

Research output: Contribution to journalArticleResearchpeer-review

Multi-methodological investigation of the variability of the microstructure of HPMC hard capsules

Faulhammer, E., Khinast, J., Paudel, A., Wahl, V. & Markl, D., 25 Sep 2016, In : International Journal of Pharmaceutics. 511, 2, p. 840-854 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Capsules
Optical Coherence Tomography
Electron Scanning Microscopy
Hot Temperature
X-Rays

NANEX: Process design and optimization

Baumgartner, R., Matic, J., Schrank, S., Laske, S., Khinast, J. & Roblegg, E., 14 Apr 2016, In : International Journal of Pharmaceutics. 506, p. 35-45 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Water
hydroxypropylmethylcellulose acetate succinate
Suspensions
Polymers
Solubility

Optimized continuous pharmaceutical manufacturing via model-predictive control

Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 16 Jun 2016, In : International Journal of Pharmaceutics. 510, p. 100-115

Research output: Contribution to journalArticleResearchpeer-review

Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

Planchette, C., Pichler, H., Wimmer-Teubenbacher, M., Gruber, M., Gruber-Wölfler, H., Mohr, S., Tetyczka, C., Hsiao, W. K., Paudel, A., Roblegg, E. & Khinast, J., 2016, In : International Journal of Pharmaceutics. p. 518-527

Research output: Contribution to journalArticleResearchpeer-review

Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective

Rehrl, J., Gruber, A. F., Khinast, J. & Horn, M., 30 Nov 2016, In : International Journal of Pharmaceutics. 517, 1-2, p. 373-382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

“Nein, die nehm’ ich nicht.“ Wie unerfüllte Erwartungen die Adhärenz von Patienten mindern.

Stegemann, S., 2016, In : Deutsche Apotheker-Zeitung. 156, 39, p. 70-74

Research output: Contribution to journalArticleResearchpeer-review

2015

Accuracy of micro powder dosing via a vibratory sieve–chute system

Besenhard, M., Faulhammer, E., Fathollahi, S., Reif, G., Calzolari, V., Biserni, S., Lawrence, S., Llusa, M. & Khinast, J., 2015, In : European journal of pharmaceutics and biopharmaceutics. 94, p. 264-272

Research output: Contribution to journalArticleResearchpeer-review

Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids

Jedinger, N., Schrank, S., Mohr, S., Feichtinger, A., Khinast, J. & Roblegg, E., 2015, In : European journal of pharmaceutics and biopharmaceutics. 92, p. 83-95

Research output: Contribution to journalArticleResearchpeer-review

A novel assay for the detection of bioactive volatiles evaluated by screening of lichen-associated bacteria

Cernava, T., Aschenbrenner, I. A., Grube, M., Liebminger, S. & Berg, G., 2015, In : Frontiers in Microbiology . 6, p. 398

Research output: Contribution to journalArticleResearchpeer-review

Volatile Organic Compounds
Lichens
Bacteria
Stenotrophomonas
Growth

Arzneimitteltherapie und Therapietreue älterer Menschen in ärztlicher und zahnärztlicher Behandlung.

Stegemann, S., 2015, In : Zeitschrift für Senioren-Zahnmedizin. 3, 2, p. 67-71

Research output: Contribution to journalArticleResearchpeer-review

Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

Markl, D., Zettl, M., Hannesschläger, G., Sacher, S., Leitner, M., Buchsbaum, A. & Khinast, J., 2015, In : Chemical Engineering Science. 125, p. 200-208

Research output: Contribution to journalArticleResearchpeer-review

Lactose
Powders
Inhalation
Capsules
Mannitol

Continuous Drying of Small Particles for Pharmaceutical Applications – An Evaluation of Selected Labscale Systems

Gursch, J., Hohl, R., Armenante, M., Dujmovic, D., van der Wel, P., Brozio, J., Krumme, M., Rasenack, N. & Khinast, J., 2015, In : Organic process research & development. 19, 12, p. 2055-2066

Research output: Contribution to journalArticleResearchpeer-review

Continuous Processing of API Suspensions via Dynamic Cross-flow Filtration

Gursch, J., Hohl, R., Toschkoff, G., Dujmovic, D., Brozio, J., Krumme, M., Rasenack, N. & Khinast, J., 2015, In : Journal of Pharmaceutical Sciences . 104, 10, p. 3481-3489

Research output: Contribution to journalArticleResearchpeer-review

Crystallization speed of salbutamol as a function of relative humidity and temperature

Zellnitz, S., Narygina, O., Resch, C., Schröttner, H. & Urbanetz, N. A., 2015, In : International Journal of Pharmaceutics. 489, p. 170-176

Research output: Contribution to journalArticleResearchpeer-review

Crystal Size Control in a Continuous Tubular Crystallizer

Besenhard, M., Neugebauer, P., Ho, C-D. & Khinast, J., 2015, In : Crystal growth & design. 15, p. 1683-1691

Research output: Contribution to journalArticleResearchpeer-review

Designed Blending for Near Infrared Calibration

Scheibelhofer, O., Grabner, B., Bondi, R. W. J., Igne, B., Sacher, S. & Khinast, J., 2015, In : Journal of Pharmaceutical Sciences . 7, 104, p. 2312-2322

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of Parameter Estimation Methods for Crystallization Processes Modeled via Population Balance Equations

Besenhard, M., Chaudhury, A., Vetter, T., Ramachandran, R. & Khinast, J., 2015, In : Chemical Engineering Research and Design / A. 94, p. 275-289

Research output: Contribution to journalArticleResearchpeer-review

Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization

Stankovic, M., 2015, In : Drug Discovery Today / Technologies . p. 812-823

Research output: Contribution to journalArticleResearchpeer-review

Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants (in press)

Stankovic, M., 2015, In : International Journal of Pharmaceutics. p. 73-83

Research output: Contribution to journalArticleResearchpeer-review

Raman spectroscopy in pharmaceutical product design

Paudel, A., Raijada, D. & Rantanen, J., 15 Jul 2015, In : Advanced Drug Delivery Reviews. 89, p. 3-20

Research output: Contribution to journalArticleResearchpeer-review

Product design
Raman spectroscopy
Structural analysis
Pharmaceutical Preparations
Quality control

Retention-time prediction for polycyclic aromatic compounds in reversed-phase capillary electro-chromatography.

Feenstra, P., Gruber-Wölfler, H., Brunsteiner, M. & Khinast, J., 2015, In : Journal of molecular modeling. 21, p. 124-133

Research output: Contribution to journalArticleResearchpeer-review

The influence of residual water on the secondary structure and crystallinity of freeze dried fibrinogen

Wahl, V., Scheibelhofer, O., Rößl, U., Leitgeb, S., deBeer, T. & Khinast, J., 2015, In : International Journal of Pharmaceutics. 484, p. 95-102

Research output: Contribution to journalArticleResearchpeer-review

The Influence of Residual Water on the Solid-State Properties of Freeze-Dried Fibrinogen

Wahl, V., Leitgeb, S., Laggner, P., Pichler, H., Liebminger, A. & Khinast, J., 2015, In : European journal of pharmaceutics and biopharmaceutics. 91, p. 1-8

Research output: Contribution to journalArticleResearchpeer-review

2014

Adult rat retinal ganglion cells and glia can be printed by piezoelectric inkjet printing

Lorber, B., Hsiao, W-K., Hutchings, I. M. & Martin, K. R., Mar 2014, In : Biofabrication. 6, 1, p. 015001

Research output: Contribution to journalArticleResearchpeer-review

Printing
Retinal Ganglion Cells
Neuroglia
Regenerative Medicine
Cell Survival

A novel method for modeling of complex wall geometries in smoothed particle hydrodynamics

Eitzlmayr, A., Koscher, G. & Khinast, J., 2014, In : Computer physics communications. 185, 10, p. 2436-2448

Research output: Contribution to journalArticleResearchpeer-review

Automatic correction for window fouling of near infrared probes in fluidised systems

Scheibelhofer, O., Hohl, R., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Sacher, S., Menezes, J. C. & Khinast, J., 2014, In : Journal of near infrared spectroscopy. 22, 3, p. 229-238

Research output: Contribution to journalArticleResearchpeer-review

Coating of glass substrates to prevent alkali ion diffusion into pharmaceutical solutions

Schweiger, S., Neubauer, C., Fraser, S., Klein, T., Schennach, R., Reichmann, A. & Gruber-Wölfler, H., 2014, In : Surface & coatings technology. 258, p. 1249-1255

Research output: Contribution to journalArticleResearchpeer-review

Condensation Reaction between Carbohydrazide and Salicylaldehyde: in-line Vibrational Spectroscopy Monitoring and Characterization of the Reaction Products in Solution and Solid State

Jednačak, T., Novak, P., Hodzic, A., Scheibelhofer, O., Khinast, J., Plavec, J., Primož, Š. & Vuković, J. P., 2014, In : Acta chimica Slovenica. 61, 1, p. 161-169

Research output: Contribution to journalArticleResearch

Continuous API-crystal coating via coacervation in a tubular reactor

Besenhard, M., Hohl, R., Thurnberger, A., Faulhammer, E. & Khinast, J., 2014, In : International Journal of Pharmaceutics. 475, p. 198-207

Research output: Contribution to journalArticleResearchpeer-review

Design of pharmaceutical products to meet future patient needs requires modification of current development paradigms and business models

Stegemann, S., Baeyens, J-P., Becker, R., Maio, M., Bresciani, M., Shreeves, T., Azadic, C., Ecker, F. & Gogol, M., 2014, In : Zeitschrift für Gerontologie + Geriatrie. 47, p. 285-287

Research output: Contribution to journalArticleResearchpeer-review

Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS

Jednačak, T., Hodzic, A., Scheibelhofer, O., Marijan, M., Khinast, J. & Novak, P., 2014, In : Acta pharmaceutica. 64, 1, p. 1-13

Research output: Contribution to journalArticleResearchpeer-review

Impact of Drying on Solid State Modifications and Drug Distribution in Ibuprofen-Loaded Calcium Stearate Pellets

Schrank, S., Kann, B., Saurugger, E-M., Ehmann, H., Werzer, O., Windbergs, M., Glasser, B. J., Zimmer, A., Khinast, J. & Roblegg, E., 2014, In : Molecular pharmaceutics. 11, 2, p. 599-609

Research output: Contribution to journalArticleResearchpeer-review

In-line implementation of an image-based particle size measurement tool to monitor hot-melt extruded pellets

Treffer, D. F., Wahl, P., Hörmann, T. R., Markl, D., Schrank, S., Jones, I., Cruise, P., Mürb, R-K., Koscher, G., Roblegg, E. & Khinast, J., 2014, In : International Journal of Pharmaceutics. 1, 2, p. 181-189

Research output: Contribution to journalArticleResearchpeer-review

In-line quality control of moving objects by means of spectral-domain OCT

Markl, D., Hannesschläger, G., Buchsbaum, A., Sacher, S., Khinast, J. & Leitner, M., 2014, In : Optics and lasers in engineering. 59, p. 1-10

Research output: Contribution to journalArticleResearchpeer-review