Research Center Pharmaceutical Engineering (RCPE) (98888)

  • 8010

    Inffeldgasse 13 Graz

    Austria

Research Output 1991 2020

2020

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

Hsiao, W-K., Hörmann, T. R., Toson, P., Paudel, A., Ghiotti, P., Stauffer, F., Bauer, F., Lakio, S., Behrend, O., Maurer, R., Holman, J. & Khinast, J., Jan 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticleResearchpeer-review

Materials science
Drug products
Processing
Industry

Model predictive control for continuous pharmaceutical feeding blending units

Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 2020, In : Chemical Engineering Research and Design / A. 2020, 154, p. 101-114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Accepted/In press) In : Advanced powder technology.

Research output: Contribution to journalArticleResearchpeer-review

Powders
Tablets
Compaction
Residence time distribution
Finite difference method

Towards a novel continuous HME-Tableting line: Process development and control concept

Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, In : European Journal of Pharmaceutical Sciences. 142

Research output: Contribution to journalArticleResearchpeer-review

2019

An evaluation of the gliding performance of solid oral dosage form film coatings using an artificial mucous layer

Drumond, N. & Stegemann, S., 1 May 2019, In : Colloids and Surfaces B: Biointerfaces. 177, p. 235-241 7 p.

Research output: Contribution to journalArticleResearchpeer-review

gliding
Dosage Forms
Polymers
coatings
Polymer films

A novel in silico scale-up approach for hot melt extrusion processes

Matic, J., Witschnigg, A., Zagler, M., Eder, S. & Khinast, J., 31 Aug 2019, In : Chemical Engineering Science. 204, p. 257-269

Research output: Contribution to journalArticleResearchpeer-review

A numerical investigation into the effect of angular particle shape on blast furnace burden topography and percolation using a GPU solved discrete element model

Govender, N., Wilke, D. N., Wu, C-Y., Tuzun, U. & Kureck, H. G., 31 Aug 2019, In : Chemical Engineering Science. p. 9-26 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Polydispersity
Blast furnaces
Topography
Coke
Ores

At-line validation of optical coherence tomography as in-line/at-line coating thickness measurement method

Wolfgang, M., Peter, A., Wahl, P., Markl, D., Zeitler, J. A. & Khinast, J. G., 15 Dec 2019, In : International Journal of Pharmaceutics. 572

Research output: Contribution to journalArticleResearchpeer-review

Can we predict trends in tribo-charging of pharmaceutical materials from first principles?

Brunsteiner, M., Zellnitz, S., Pinto, J. T., Karrer, J. & Paudel, A., 1 Nov 2019, In : Powder Technology. 356, p. 892-898 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionization potential
Drug products
Pharmaceutical Preparations
Discrete Fourier transforms
Electronic structure

Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater

Boehling, P., Khinast, J. G., Jajcevic, D., Davies, C., Carmody, A., Doshi, P., Ende, M. T. A. & Sarkar, A., Jan 2019, In : Journal of Pharmaceutical Sciences . 108, 1, p. 538-550

Research output: Contribution to journalArticleResearchpeer-review

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In : International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational fluid dynamics
Fires
X ray photoelectron spectroscopy
Momentum transfer
Drug products

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings

Koutsamanis, I., Eder, S., Beretta, M., Witschnigg, A., Paudel, A., Nickisch, K., Friedrich, M., Eggenreich, K. & Roblegg, E., 10 Jun 2019, In : International Journal of Pharmaceutics. 564, p. 90-97 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Female Contraceptive Devices
Membranes
Polymers
Hormone Replacement Therapy
Silicones
Near-Infrared Spectroscopy
Optical Coherence Tomography
Tablets
Weights and Measures
Dosage Forms

Impact of drug particle shape on permeability and cellular uptake in the lung

Zellnitz, S., Zellnitz, L., Müller, M. T., Meindl, C., Schröttner, H. & Fröhlich, E., 1 Nov 2019, In : European Journal of Pharmaceutical Sciences. 139, 105065.

Research output: Contribution to journalArticleResearchpeer-review

Albuterol
Permeability
Budesonide
Macrophages
Lung

IMPACT OF RELATIVE HUMIDITY AND POWDER FILLING LEVEL ON THE ELECTROSTATIC CHARGING BEHAVIOUR OF DIFFERENT CAPSULE TYPES

Wutscher, T., Zellnitz, S., Kobler, M., Buttini, F., Andrade, L., Daza, V., Mercandelli, A., Biserni, S., Ecenarro Probst, S., Khinast, J. & Paudel, A., 1 Apr 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery . 32, 2, p. A9-A10

Research output: Contribution to journalAbstractResearchpeer-review

Open Access
Particle Size
Linear Models
Pharmaceutical Preparations
Temperature

Industrial scale simulations of tablet coating using gpu based dem: A validation study

Kureck, H. G., Govender, N., Siegmann, E., Böhling, P., Radeke, C. & Khinast, J., 20 Jul 2019, In : Chemical Engineering Science. p. 462-480 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Tablets
Coatings
Computational methods
Finite difference method
Costs

Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment

Radivojev, S., Pinto, J. T., Fröhlich, E. & Paudel, A., 1 Aug 2019, In : Journal of Drug Delivery Science and Technology. 52, p. 803-817 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Dry Powder Inhalers
Humidity
Budesonide
Computer Simulation
Powders

Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

Pietsch, S., Peter, A., Wahl, P., Khinast, J. & Heinrich, S., Nov 2019, In : Powder Technology. 356, p. 139-147

Research output: Contribution to journalArticleResearchpeer-review

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Karttunen, A. P., Hörmann, T. R., De Leersnyder, F., Ketolainen, J., De Beer, T., Hsiao, W. K. & Korhonen, O., 30 May 2019, In : International Journal of Pharmaceutics. 563, p. 184-197 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Video Recording
Color
Pharmaceutical Preparations

Measuring bulk density variations in a moving powder bed via terahertz in-line sensing

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Khinast, J. G., Zeitler, J. A. & Markl, D., 15 Feb 2019, In : Powder Technology. 344, p. 152-160

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic modelling of fluid bed granulation, Part II: Eased process development via degree of wetness

Askarishahi, M., Salehi, M. S., Maus, M., Schröder, D., Slade, D. & Jajcevic, D., 15 Dec 2019, In : International Journal of Pharmaceutics. 572, 118836.

Research output: Contribution to journalArticleResearchpeer-review

Temperature
Hot Temperature
Costs and Cost Analysis
Population

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson, P., Lopes, D. G., Paus, R., Kumar, A., Geens, J., Stibale, S., Quodbach, J., Kleinebudde, P., Hsiao, W-K. & Khinast, J., Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100005.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Drug products
Compaction
Throughput
Design of experiments
Process design

MULTISCALE MODELING OF A PHARMACEUTICAL FLUID BED COATING PROCESS USING CFD/DEM AND POPULATION BALANCE MODELS TO PREDICT COATING UNIFORMITY

Sarkar, A., Shoemaker, B., Doshi, P., am Ende, M. T., Jajcevic, D., Böhling, P., Toson, P., Zadravec, M., Khinast, J. G., Ende, M. T. A. (ed.) & am Ende, D. J. (ed.), 12 Apr 2019, Chemical Engineering in the Pharmaceutical Industry.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Oxygen sensors for flow reactors-measuring dissolved oxygen in organic solvents

Sulzer, P., Lebl, R., Kappe, C. O. & Mayr, T., 1 Dec 2019, In : Reaction Chemistry and Engineering. 4, 12, p. 2081-2087 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Oxygen sensors
Dissolved oxygen
Organic solvents
Sensors
Oxygen

Particle-level residence time data in a twin-screw feeder

Toson, P. & Khinast, J. G., Dec 2019, In : Data in Brief . 27, 104672

Research output: Contribution to journalArticleResearchpeer-review

Particle-Level Residence Time Data in a Twin-Screw Feeder

Toson, P. & Khinast, J., 22 Oct 2019

Research output: Non-print formData set/DatabaseResearch

Open Access

Performance Characterization of Static Mixers in Precipitating Environments

Kreimer, M., Zettl, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. G. & Krumme, M., Jul 2019, In : Organic process research & development. 23, 7, p. 1308-1320

Research output: Contribution to journalArticleResearchpeer-review

Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Zeitler, J. A., Biserni, S., Calzolari, V., Khinast, J. G. & Markl, D., 1 Dec 2019, In : International Journal of Pharmaceutics: X. 1, 100004.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Powders
Capsules
Technology
Weights and Measures
Specific Gravity

Predicting the formation of satellite droplets in inkjet printing

Planchette, C., Brenn, G., Marangon, F. & Hsiao, W. K., 2019, (Accepted/In press) In : Physical Review Fluids. 2019

Research output: Contribution to journalArticleResearchpeer-review

Pvp-h2o2 complex as a new stressor for the accelerated oxidation study of pharmaceutical solids

Modhave, D., Barrios, B. & Paudel, A., 1 Sep 2019, In : Pharmaceutics . 11, 9, 457.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Excipients
Peroxides
Pharmaceutical Preparations
Hydrogen Peroxide
Povidone

Real-time measurement of coating film thickness

Wolfgang, M., Wahl, P., Sacher, S., Gartshein, E. & Khinas, J. G., 1 Mar 2019, In : Pharmaceutical technology. 43, 3, p. 36-47 12 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs

Radivojev, S., Zellnitz, S., Paudel, A. & Froehlich, E., 10 Feb 2019, In : International Journal of Pharmaceutics. 556, p. 45-56 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Inhalation
Pharmaceutical Preparations
Particle Size
Computer Simulation
Solubility

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In : International Journal of Pharmaceutics. 566, p. 57-66

Research output: Contribution to journalArticleResearchpeer-review

Solids Mixing Rates of Geldart A and B Powders Predicted by the Two Fluid Model

Salehi, M., Askarishahi, M. & Radl, S., 12 Nov 2019.

Research output: Contribution to conferencePosterResearchpeer-review

Powders
Fluids
Fluidization
Mass transfer
Particle size

Solvent Resistant O2 Sensor Integrated in Pressured Flow Reactors

Sulzer, P., Lebl, R. & Mayr, T., 16 Jan 2019, In : Proceedings MDPI. 2, 13, 4 p., 994.

Research output: Contribution to journalConference articleResearchpeer-review

Open Access
Fluorometers
Calibration
Oxygen sensors
Sensors
Optical sensors

Study of the capsule-filling dosator process via calibrated DEM simulations

Madlmeir, S., Loidolt, P. & Khinast, J. G., 15 Aug 2019, In : International Journal of Pharmaceutics. 567

Research output: Contribution to journalArticleResearchpeer-review

TFM-based Full Physics Simulations of Mixing in Non-Cohesive Wet Fluidized Beds

Askarishahi, M., Salehi, M. & Radl, S., 12 Jun 2019, (Accepted/In press) In : Industrial and Engineering Chemistry Research.

Research output: Contribution to journalArticleResearchpeer-review

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In : Pharmaceutical development and technology. 24, 6, p. 739-750 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Particulate Matter
Process Assessment (Health Care)
Risk Management
Patient Safety
Guidelines

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, In : Pharmaceutical research. 36, 6, p. 80 11 p., 36:80.

Research output: Contribution to journalArticleResearchpeer-review

Two-Fluid-Model-Based Full Physics Simulations of Mixing in Noncohesive Wet Fluidized Beds

Askarishahi, M., Salehi, M. S. & Radl, S., 10 Jul 2019, In : Industrial and Engineering Chemistry Research. 58, 27, p. 12323-12346 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluidized beds
Physics
Drying
Fluids
Spraying
2018

3D printing of oral drugs: a new reality or hype?

Hsiao, W. K., Lorber, B., Reitsamer, H. & Khinast, J., 2 Jan 2018, In : Expert opinion on drug delivery. 15, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorialResearchpeer-review

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, In : Powder Technology. 337, p. 3-16 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Rolls (machine components)
Finite difference method
Compaction
Powders
Finite element method

Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs

Bäckman, P., Arora, S., Couet, W., Forbes, B., de Kruijf, W. & Paudel, A., 15 Feb 2018, In : European Journal of Pharmaceutical Sciences. 113, p. 41-52 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhalation Exposure
Computer Simulation
Lung
Pharmaceutical Preparations
Aerosols

A multivariate process monitoring strategy and control concept for a small-scale fermenter in a PAT environment

Besenhard, M. O., Scheibelhofer, O., François, K., Joksch, M. & Kavsek, B., 1 Oct 2018, In : Journal of Intelligent Manufacturing. 29, 7, p. 1501-1514 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fermenters
Process monitoring
Process control
Fermentation
Yeast

Assessment of Dry Powder Inhaler Carrier Targeted Design: A Comparative Case Study of Diverse Anomeric Compositions and Physical Properties of Lactose

Pinto, J. T., Zellnitz, S., Guidi, T., Roblegg, E. & Paudel, A., 1 Jun 2018, In : Molecular pharmaceutics. 15, 7, p. 2827-2839

Research output: Contribution to journalArticleResearchpeer-review

Dry Powder Inhalers
Lactose
Adhesives
Gas Lasers
Surface Properties

A system and a method for constant micro dosing and feeding of powder material

Fathollahi, S., Khinast, J., Klein, T., Besenhard, M. & Slama, E., 11 Apr 2018

Research output: PatentResearch

Benchmarking a Novel 0-D Model Against Data from Two-Fluid Model Simulations of a Wet Fluidized Bed

Radl, S., Salehi, M. & Askarishahi, M., 29 Oct 2018, AIChE Annual Meeting 2018.

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Open Access
File
benchmarking
fluid
simulation
droplet
spray