• 8010

    Petersgasse 10-12 Graz

    Austria

Organization profile

Profile Information

Description of the research groups: “Bio/Technology group” (Univ.-Prof. DI Dr. Bernd Nidetzky) This group carries out basic research on enzyme catalysis and studies bioprocess development using enzymes as the biocatalysts. The concept is to build on the understanding of fundamental kinetic and chemical mechanisms of the enzymatic reaction and move toward real application by analyzing interactions between biochemical and physical factors that occur on the process scale. The research focuses on enzymes that can make glycosidic bonds between sugar units (glycobiotechnology) and catalyze oxidoreductive biotransformations. We aim at utilizing renewable carbohydrate-based resources such as lignocellulose, starch, sucrose, or lactose for the production of functional “sugars” to be used in medicine or for food and feed applications. We explore novel enzymes from nature, try to understand how enzymes of interest work by using a detailed structure and function analysis, and design improved processes by targeted modifications of enzyme properties (such as specificity or stability) and innovative reaction engineering. "Applied Microbial Physiology" (Univ.-Prof. DI Dr. Gerhart Braunegg) The research group is engaged in the development of different biotechnological processes. Based on the knowledge of microbial physiology and fermentation technology microbial growth and product formation are optimized. The research group is working on processes for Polyhydroxyalkanoates (PHAs) production from different agricultural waste materials. PHA are biopolyesters accumulated intracellularly in procaryonts up to high quantities and are produced from renewable substrates and due to their properties are similar to oil-born thermoplasts. Another task is the stereospecific hydroxylation of non activated carbon atoms in compounds synthesized by the Institute of Organic Chemistry with fungi and bacteria. Fermentation conditions are optimized to get optically pure products in high yields. Heavy metals are leached by different microorganisms (bacteria and fungi) from ash fractions derived from biomass combustion and gasification plants. Conditions for microbial leaching are optimized, and the separation of the heavy metals from the leachate is performed by microorganisms accumulating these compounds intra- or extracellularly. Enzyme-Technology (Univ.-Prof. DI Dr. Walter Steiner) The research is focused on the biotechnological production, purification and characterisation of industrially important enzymes. Besides the use of different optimisation strategies for experimental design and process development the attention is directed towards intensive kinetic analysis of the reactions involved. The main research areas are enzymes involved in the degradation and synthesis of biopolymers like hydrolysis of plant biomass and oligosacchidsynthesis. Furthermore enzymes for pulp and paper industries applied in biobleaching and deinking are under investigation. Moreover enzymes from "Extremophiles" (xylanases, endoglucanases, etc) and enzymes used in "Biocatalysis and Biotransformations" (hydroxynitrile lyases, lipases) are studied within the frame of national (SFB) and international (EC) joint research programmes. Short Description: The Institute of Biotechnology and Biochemical Engineering is the main Austrian university institution for basic and applied research at the interface of biological sciences and process engineering. The aim is to achieve innovative solutions for efficient and accelerated process development in biotechnology using an integrated scientific-technological approach that combines modern methods of molecular and process bioengineering. The research activities are focused on three main fields: applied enzymology and enzyme technology; metabolic and reaction engineering for biocatalysis and renewable resource utilization; and glycobiotechnology.

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Enzymes Engineering & Materials Science
Glucose Engineering & Materials Science
Sugar (sucrose) Engineering & Materials Science
Glycosyltransferases Chemical Compounds
Immobilized Enzymes Chemical Compounds
Oxidoreductases Chemical Compounds
Biocatalysts Engineering & Materials Science
Diphosphates Chemical Compounds

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Research Output 1966 2020

Enzyme Immobilization in Wall-Coated Flow Microreactors

Valikhani, D., Bolivar, J. M. & Nidetzky, B., 1 Jan 2020, In : Methods in molecular biology (Clifton, N.J.). 2100, p. 243-257 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Immobilization
Enzymes
sucrose phosphorylase
Silicon Dioxide
Glass

Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

Wiltschi, B., Cernava, T., Dennig, A., Galindo, M., Geier, M., Gruber, S., Haberbauer, M., Heidinger, P., Acero, E. H., Kratzer, R., Luley-Goedl, C., Müller, C. A., Pitzer, J., Ribitsch, D., Sauer, M., Schmölzer, K., Schnitzhofer, W., Sensen, C. W., Soh, J., Steiner, K. & 3 othersWinkler, C. K., Winkler, M. & Wriessnegger, T., 22 Jan 2020, In : Biotechnology Advances. p. 107520

Research output: Contribution to journalArticleResearchpeer-review

Enzymes
Recovery
Biocontrol
Bioconversion
Biocatalysts

Intraparticle pH Sensing Within Immobilized Enzymes: Immobilized Yellow Fluorescent Protein as Optical Sensor for Spatiotemporal Mapping of pH Inside Porous Particles

Consolati, T., Bolivar, J. M., Petrasek, Z., Berenguer, J., Hidalgo, A., Guisan, J. M. & Nidetzky, B., 1 Jan 2020, In : Methods in molecular biology (Clifton, N.J.). 2100, p. 319-333 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Immobilized Enzymes
Proteins
Enzymes
Penicillin Amidase
Proton-Motive Force

Activities 1988 2019

CDP-paratose 2-epimerase: substrate specificity beyond expectation

Bernd Nidetzky (Speaker)
30 Jun 20194 Jul 2019

Activity: Talk or presentationTalk at conference or symposiumScience to science

Alternative application of aldolase or synthase in optimized multi-enzyme cascade production of 3’-sialyllactose

Bernd Nidetzky (Speaker)
30 Jun 20194 Jul 2019

Activity: Talk or presentationTalk at conference or symposiumScience to science

Next generation bioproduction – the importance of not getting lost in translation

Bernd Nidetzky (Speaker)
28 Mar 2019

Activity: Talk or presentationTalk at conference or symposiumScience to science

Prizes

Anton Paar Science Award

Grit Daniela Straganz (Recipient), 11 Sep 2007

Prize: Prizes / Medals / Awards

science

Best Talk Award - Life Sciences 2008

Stefan Krahulec (Recipient), 24 Sep 2008

Prize: Prizes / Medals / Awards

life sciences

Biotrans Poster Award

Margit Winkler (Recipient), 30 Jul 2015

Prize: Prizes / Medals / Awards

Press / Media

Plastische Vorstellung. Biologische Kunststoffe in Medizin, Autoproduktion und Verpackungsindustrie

Martin Koller

20/11/13

1 media contribution

Press/Media: Press / Media

Bioimplantate: Neues aus der Öko-Chirurgie

Martin Koller

24/10/13

1 media contribution

Press/Media: Press / Media

Medizinische Nägel werden abbaubar

Martin Koller

9/09/13

1 media contribution

Press/Media: Press / Media

Projects 1992 2023