Pressurized CO2 as a carboxylating agent for the biocatalytic: Ortho -carboxylation of resorcinol

Katharina Plasch, Gerhard Hofer, Walter Keller, Sam Hay, Derren J. Heyes, Alexander Dennig, Silvia M. Glueck, Kurt Faber

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (∼30-40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.

Original languageEnglish
Pages (from-to)1754-1759
Number of pages6
JournalGreen chemistry
Volume20
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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    Plasch, K., Hofer, G., Keller, W., Hay, S., Heyes, D. J., Dennig, A., ... Faber, K. (2018). Pressurized CO2 as a carboxylating agent for the biocatalytic: Ortho -carboxylation of resorcinol. Green chemistry, 20(8), 1754-1759. https://doi.org/10.1039/c8gc00008e