Pressurized CO2 as a carboxylating agent for the biocatalytic: Ortho -carboxylation of resorcinol

Katharina Plasch, Gerhard Hofer, Walter Keller, Sam Hay, Derren J. Heyes, Alexander Dennig, Silvia M. Glueck*, Kurt Faber

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (∼30-40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.

Originalspracheenglisch
Seiten (von - bis)1754-1759
Seitenumfang6
FachzeitschriftGreen Chemistry
Jahrgang20
Ausgabenummer8
DOIs
PublikationsstatusVeröffentlicht - 1 Jan 2018

ASJC Scopus subject areas

  • Umweltchemie
  • !!Pollution

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