New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins

Herwig Prasch, Cornelia Hojnik, Thisbe K. Lindhorst, Blanka Didak, Ludovic Landemarre, Tanja M. Wrodnigg*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, D-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalCarbohydrate Research
Volume475
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Amadori rearrangement
  • Antiadhesives
  • C-Glycosyl-type glycoconjugates
  • Carbohydrate-lectin interactions
  • Inhibition assay

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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