1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, D-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.
- Amadori rearrangement
- C-Glycosyl-type glycoconjugates
- Carbohydrate-lectin interactions
- Inhibition assay
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry