New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins

Herwig Prasch, Cornelia Hojnik, Thisbe K. Lindhorst, Blanka Didak, Ludovic Landemarre, Tanja M. Wrodnigg*

*Korrespondierende/r Autor/in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikel

Abstract

1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, d-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.
Originalspracheenglisch
Seiten (von - bis)65-68
Seitenumfang4
FachzeitschriftCarbohydrate Research
Jahrgang475
DOIs
PublikationsstatusVeröffentlicht - 1 Mär 2019

ASJC Scopus subject areas

  • Analytische Chemie
  • !!Biochemistry
  • Organische Chemie

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