A scalable process to produce lipid-based compartmented: Janus nanoparticles with pharmaceutically approved excipients

Tri Truong-Cong, Elodie Millart, Le Tuyet Chau Tran, Heinz Amenitsch, Ghislaine Frebourg, Sylviane Lesieur, Vincent Faivre

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the preparation and characterization of lipid-based Janus compartmented nanoparticles. They were successfully prepared using a scalable process with pharmaceutically approved excipients. The analysis of the microscopic structure and supramolecular organization demonstrated the formation of two physico-chemically different compartments enabling the co-administration at once of both liposoluble and hydrosoluble active pharmaceutical ingredients.

Original languageEnglish
Pages (from-to)3654-3662
Number of pages9
JournalNanoscale
Volume10
Issue number8
DOIs
Publication statusPublished - 28 Feb 2018

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ASJC Scopus subject areas

  • Materials Science(all)

Fields of Expertise

  • Human- & Biotechnology

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