A scalable process to produce lipid-based compartmented: Janus nanoparticles with pharmaceutically approved excipients

Tri Truong-Cong, Elodie Millart, Le Tuyet Chau Tran, Heinz Amenitsch, Ghislaine Frebourg, Sylviane Lesieur, Vincent Faivre*

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the preparation and characterization of lipid-based Janus compartmented nanoparticles. They were successfully prepared using a scalable process with pharmaceutically approved excipients. The analysis of the microscopic structure and supramolecular organization demonstrated the formation of two physico-chemically different compartments enabling the co-administration at once of both liposoluble and hydrosoluble active pharmaceutical ingredients.

Originalspracheenglisch
Seiten (von - bis)3654-3662
Seitenumfang9
FachzeitschriftNanoscale
Jahrgang10
Ausgabenummer8
DOIs
PublikationsstatusVeröffentlicht - 28 Feb. 2018

ASJC Scopus subject areas

  • Werkstoffwissenschaften (insg.)

Fields of Expertise

  • Human- & Biotechnology

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