Description
Our group is engaged in the synthesis and chemical modification of some of these glycosidase inhibitors as well as in close co-operation with an international team of groups for example from the University of British Columbia, Vancouver, from CSIRO, Melbourne, and from the Technical University of Denmark, Lyngby-Copenhagen - with the biological evaluation of these products. With the aid of computer supported molecular modeling studies and in collaboration with internationally leading crystallographers, the interactions of some of these compounds with the active site of selected enzymes can be explored to gain increasing information on the structure-activity-relationships in this class of inhibitors.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/95 → 31/01/07 |
Related content
Research Outputs
Non-natural aldofuranosides as substrates of a beta-glucosidase
Research output: Contribution to journal › Article › Research › peer-review
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Novel probes for the active site of alpha-amylase: Syntheses of glycosylated carbacycles
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Fluorescent probes: Tagged iminoalditols as reversible glycosidase inhibitors
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
A simple method for the preparation of 1-deoxynojirimycin from D-fructose
Research output: Contribution to journal › Article › Research › peer-review
Simple syntheses of 4-O-glucosylated 1-deoxynojirimycins from maltose and cellobiose
Research output: Contribution to journal › Article › Research › peer-review
A novel innovative approach aims to clarify the reaction mechanism of retaining glycoside hydrolases
Research output: Contribution to journal › Article › Research › peer-review
Synthesis of O-glycosylated1,5-dideoxy-1,5-imino-D-glucitol derivatives from the corresponding disaccharides
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Chemical and chemo-enzymatic approaches to unnatural ketoses and glycosidase inhibitors with basic nitrogen in the sugar ring
Research output: Contribution to journal › Article › Research › peer-review
Synthesis of 1-amino-1,2,5-trideoxy-2,5-imino-D-mannitol, a novel analogue of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol, via an Amadori rearrangement of 5-azido-5-deoxy-D-glucofuranose
Research output: Contribution to journal › Article › Research › peer-review
Tables of glycosidase inhibitors with basic nitrogen in the sugar ring and their inhibitory activities
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
Research output: Contribution to journal › Article › Research › peer-review
Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols
Research output: Contribution to journal › Article › Research › peer-review
Novel lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors
Research output: Contribution to journal › Article › Research › peer-review
Syntheses of sugar related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors
Research output: Contribution to journal › Article › Research › peer-review
Synthesis of a novel alpha-glucoside of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol via enzymatic glucosylation of 5-azido-5-deoxy-D-glucofuranose
Research output: Contribution to journal › Article › Research › peer-review
Hexa-O-benzyl-5-hydroxy-pseudo-alpha-D-glucopyranose and its C-5 epimer
Research output: Contribution to journal › Article › Research › peer-review
Synthesis of (1-13C)-1-deoxynojirimycin
Research output: Contribution to journal › Article › Research › peer-review
Biologically active 1-aminodeoxy derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol
Research output: Contribution to journal › Article › Research › peer-review
Chemical and chemo-enzymatc approaches to glycosidase inhibitors with basic nitrogen in the sugar ring
Research output: Contribution to journal › Article › Research › peer-review
Characterisation and functional purification of a beta-xylosidase from potato
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
L-Idoseptanosides: substrates of D-glucosidases
Research output: Contribution to journal › Article › Research › peer-review
2,5-dideoxy-2,5-imino-D-mannitol and -D-glucitol. Two step bio-organic syntheses from 5-azido-5-deoxy-D-glucofuranose and -L-idofuranose, respectively, evaluation as glucosidase inhibitors and an application in affinity purification and....
Research output: Contribution to journal › Article › Research › peer-review
A simple and convergent synthesis of the mannosidase inhibitor 1-deoxymannonojirimycin from sucrose
Research output: Contribution to journal › Article › Research › peer-review
Stability of endo-mannosidase inhibitor 3-O-a-D-glucopyranosyl-1-deoxynojirimycin and its derivatives towards a-glucosidases
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Some reflections on structure-activity relationships in glycosidase inhibiting iminoalditols and iminosugars
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research
C-Glycoside von 4-amino-4-desoxy-D-arabinofuranose: Zwischenprodukte en route zu glycosidasenhemmenden Broussonetinen
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Timely research perspectives in carbohydrate chemistry
Research output: Book/Report › Book › Research
Easy access to 6-membered iminoalditols - important glycosidase inhibitors
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Novel diagnostic tools: Fluorescently tagged iminoalditols as glycosidase inhibitors
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Synthesis of powerful endoglycosidase inhibitors from reducing disaccharides
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Iminosugars as glycosidase inhibitors
Research output: Book/Report › Book › Research
Einfache Synthesen von 1,5-didesoxy-1,5-imino-D-glucit (1-Desoxynojirimycin) und 1,6-Didesoxy-1,6-imino-D-glucit aus D-Glucofuranurono-6,3-lacton
Research output: Contribution to journal › Article › Research › peer-review
GlycoGroup, Arbeitsgruppe für Glycochemie und Glycotechnologie
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Golgi endomannosidase inhibitor, alpha-D-glucopyranosyl-(1-3)-1-deoxynojirimycin: A five step synthesis from maltulose and examples of N-modified derivatives
Research output: Contribution to journal › Article › Research › peer-review
First synthesis of (1R,2R,3S,9S,9aR)-1,2,3,9-tetrahydroxyquinolizidine, a novel isosteric homologue of the glucosidase inhibitor castanospermine
Research output: Contribution to journal › Article › Research › peer-review
Epimerisation, isomerisation and rearrangement reactions of carbohydrates
Research output: Book/Report › Book › Research
Powerful probes for glycosidases: Novel fluorescently tagged glycosidase inhibitors
Research output: Contribution to journal › Article › Research › peer-review
Iminoalditols as affinity ligands for the isolation of glycosidases
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research
4-O-Glycosylated 1-deoxynojirimycins from maltose and cellobiose
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Synthesis of regio- and stereospecifically C-deuterated derivatives of glycosidase inhibitors 1-deoxymannojirimycin and 2,5-dideoxy-2,5-imino-D-mannitol by intramolecular reductive amination employing deuterium gas
Research output: Contribution to journal › Article › Research › peer-review
Einfache Synthese von 1,5,6-Tridesoxy-6-fluor-1,5-imino-D-glucit, dem ersten fluorhältigen Derivat des Glucosidaseninhibitors 1-Desoxynojirimycin
Research output: Contribution to journal › Article › Research › peer-review
Synthese von fluoreszenzmarkierten Iminoalditolen und deren Evaluierung als biologische Werkzeuge und Diagnostika
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Synthese von (+)-Castanospermin und 1-epi-Castanospermin aus D-Glucofuranurono-6,3-lacton durch Reformatsky-Reaktion
Research output: Contribution to journal › Article › Research › peer-review
N-Alkylated Derivatives of 1,5-Dideoxy-1,5-iminoxylitol as beta-Xylosidase and beta-Glucosidase Inhibitors
Research output: Contribution to journal › Article › Research › peer-review
Two isosteric fluorinated derivatives of the powerful glucosidase inhibitors 1-deoxynojirimycin and 2,5-dideoxy-2,5-imino-D-mannitol: Syntheses and glucosidase inhibitory activities of 1,2,5-trideoxy-2-fluoro-1,5-imino-D-glucitol and of....
Research output: Contribution to journal › Article › Research › peer-review
Preparation of partially protected iminosugar analogues of glucosaminoglycan building blocks
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
A novel approach to the 1-deoxynojirimycin system: Synthesis, from sucrose, of 2-acetamido-1,2-dideoxynojirimycin as well as some 2-N-modified derivatives
Research output: Contribution to journal › Article › Research › peer-review
Projects
Glycoside hydrolases
Project: Research project
Natural Product Chemistry
Project: Research project
Enzyme Catalysed Organic Reactions - General Biocatalysis
Project: Research project
Glycochemistry and Glycotechnology
Project: Research area