Sodium transients in an astrocyte

Kerstin Lenk; Aapo Tervonen; Jari Hyttinen

doi:10.3217/978-3-85125-826-4-03

Sodium transients in an astrocyte

Kerstin Lenk^*, Aapo Tervonen, Jari Hyttinen

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Neurotechnologie (7090)

Publikation: Beitrag in Buch/Bericht/Konferenzband › Beitrag in einem Konferenzband › Begutachtung

Abstract

Astrocytes, a type of glial cells in the brain, are actively involved in neuronal information processing and memory formation. An astrocyte participates in neuronal activity by receiving neuro-transmitters, e.g., glutamate, from an adjacent pre-synapse. This leads to the propagation of astrocytic
intra- and intercellular calcium waves. In this study,we extend the computational model presented by Oschmann et al. (2017) to a finite element model of
single astrocytes, including a realistic 2D geometry and inositol 1,4,5-trisphosphate (IP3) and ion diffusion. Here, we conduct a parameter exploration of the sodium-calcium exchanger (NCX) and sodium-potassium-ATPase (NKA) rate constants. The calcium concentration directly depends on the amplitude
of the glutamate stimulus. However, the sodium concentration instead relates only to the sodium-potassium pump activity.

Originalsprache	englisch
Titel	Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021
Untertitel	ÖGBMT 2021
Redakteure/-innen	Gernot R. Müller-Putz, Christian Baumgartner
Erscheinungsort	Graz
Herausgeber (Verlag)	Verlag der Technischen Universität Graz
Seiten	9-12
ISBN (elektronisch)	978-3-85125-826-4
DOIs	https://doi.org/10.3217/978-3-85125-826-4-03
Publikationsstatus	Veröffentlicht - 2021
Veranstaltung	ÖGBMT Jahrestagung 2021: ÖGBMT 2021 - Graz University of Technology, Graz, Österreich Dauer: 30 Sept. 2021 → 1 Okt. 2021 https://oegbmt2021.tugraz.at/

Konferenz

Konferenz	ÖGBMT Jahrestagung 2021
Kurztitel	ÖGBMT 2021
Land/Gebiet	Österreich
Ort	Graz
Zeitraum	30/09/21 → 1/10/21
Internetadresse	https://oegbmt2021.tugraz.at/

Fields of Expertise

Human- & Biotechnology

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10.3217/978-3-85125-826-4-03Lizenz: CC BY 4.0

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Sodium transients in an astrocyte. / Lenk, Kerstin; Tervonen, Aapo; Hyttinen, Jari.
Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021: ÖGBMT 2021. Hrsg. / Gernot R. Müller-Putz; Christian Baumgartner. Graz: Verlag der Technischen Universität Graz, 2021. S. 9-12.

Publikation: Beitrag in Buch/Bericht/Konferenzband › Beitrag in einem Konferenzband › Begutachtung

Lenk, K, Tervonen, A & Hyttinen, J 2021, Sodium transients in an astrocyte. in GR Müller-Putz & C Baumgartner (Hrsg.), Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021: ÖGBMT 2021. Verlag der Technischen Universität Graz, Graz, S. 9-12, ÖGBMT Jahrestagung 2021, Graz, Österreich, 30/09/21. https://doi.org/10.3217/978-3-85125-826-4-03

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title = "Sodium transients in an astrocyte",

abstract = "Astrocytes, a type of glial cells in the brain, are actively involved in neuronal information processing and memory formation. An astrocyte participates in neuronal activity by receiving neuro-transmitters, e.g., glutamate, from an adjacent pre-synapse. This leads to the propagation of astrocyticintra- and intercellular calcium waves. In this study,we extend the computational model presented by Oschmann et al. (2017) to a finite element model ofsingle astrocytes, including a realistic 2D geometry and inositol 1,4,5-trisphosphate (IP3) and ion diffusion. Here, we conduct a parameter exploration of the sodium-calcium exchanger (NCX) and sodium-potassium-ATPase (NKA) rate constants. The calcium concentration directly depends on the amplitudeof the glutamate stimulus. However, the sodium concentration instead relates only to the sodium-potassium pump activity.",

author = "Kerstin Lenk and Aapo Tervonen and Jari Hyttinen",

year = "2021",

doi = "10.3217/978-3-85125-826-4-03",

language = "English",

pages = "9--12",

editor = "M{\"u}ller-Putz, {Gernot R.} and Baumgartner, {Christian }",

booktitle = "Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021",

publisher = "Verlag der Technischen Universit{\"a}t Graz",

note = "Annual Meeting of the Austrian Society of the Biomedical Engineering 2021 : {\"O}GBMT 2021, {\"O}GBMT 2021 ; Conference date: 30-09-2021 Through 01-10-2021",

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TY - GEN

T1 - Sodium transients in an astrocyte

AU - Lenk, Kerstin

AU - Tervonen, Aapo

AU - Hyttinen, Jari

PY - 2021

Y1 - 2021

N2 - Astrocytes, a type of glial cells in the brain, are actively involved in neuronal information processing and memory formation. An astrocyte participates in neuronal activity by receiving neuro-transmitters, e.g., glutamate, from an adjacent pre-synapse. This leads to the propagation of astrocyticintra- and intercellular calcium waves. In this study,we extend the computational model presented by Oschmann et al. (2017) to a finite element model ofsingle astrocytes, including a realistic 2D geometry and inositol 1,4,5-trisphosphate (IP3) and ion diffusion. Here, we conduct a parameter exploration of the sodium-calcium exchanger (NCX) and sodium-potassium-ATPase (NKA) rate constants. The calcium concentration directly depends on the amplitudeof the glutamate stimulus. However, the sodium concentration instead relates only to the sodium-potassium pump activity.

AB - Astrocytes, a type of glial cells in the brain, are actively involved in neuronal information processing and memory formation. An astrocyte participates in neuronal activity by receiving neuro-transmitters, e.g., glutamate, from an adjacent pre-synapse. This leads to the propagation of astrocyticintra- and intercellular calcium waves. In this study,we extend the computational model presented by Oschmann et al. (2017) to a finite element model ofsingle astrocytes, including a realistic 2D geometry and inositol 1,4,5-trisphosphate (IP3) and ion diffusion. Here, we conduct a parameter exploration of the sodium-calcium exchanger (NCX) and sodium-potassium-ATPase (NKA) rate constants. The calcium concentration directly depends on the amplitudeof the glutamate stimulus. However, the sodium concentration instead relates only to the sodium-potassium pump activity.

U2 - 10.3217/978-3-85125-826-4-03

DO - 10.3217/978-3-85125-826-4-03

M3 - Conference paper

SP - 9

EP - 12

BT - Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021

A2 - Müller-Putz, Gernot R.

A2 - Baumgartner, Christian

PB - Verlag der Technischen Universität Graz

CY - Graz

T2 - Annual Meeting of the Austrian Society of the Biomedical Engineering 2021

Y2 - 30 September 2021 through 1 October 2021

ER -

Sodium transients in an astrocyte

Abstract

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