Sodium transients in an astrocyte

Kerstin Lenk*, Aapo Tervonen, Jari Hyttinen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Abstract

Astrocytes, a type of glial cells in the brain, are actively involved in neuronal information processing and memory formation. An astrocyte participates in neuronal activity by receiving neuro-transmitters, e.g., glutamate, from an adjacent pre-synapse. This leads to the propagation of astrocytic
intra- and intercellular calcium waves. In this study,we extend the computational model presented by Oschmann et al. (2017) to a finite element model of
single astrocytes, including a realistic 2D geometry and inositol 1,4,5-trisphosphate (IP3) and ion diffusion. Here, we conduct a parameter exploration of the sodium-calcium exchanger (NCX) and sodium-potassium-ATPase (NKA) rate constants. The calcium concentration directly depends on the amplitude
of the glutamate stimulus. However, the sodium concentration instead relates only to the sodium-potassium pump activity.
Original languageEnglish
Title of host publicationProceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021
Subtitle of host publicationÖGBMT 2021
EditorsGernot R. Müller-Putz, Christian Baumgartner
Place of PublicationGraz
PublisherVerlag der Technischen Universität Graz
Pages9-12
ISBN (Electronic)978-3-85125-826-4
DOIs
Publication statusPublished - 2021
EventAnnual Meeting of the Austrian Society of the Biomedical Engineering 2021: ÖGBMT 2021 - Graz University of Technology, Graz, Austria
Duration: 30 Sep 20211 Oct 2021
https://oegbmt2021.tugraz.at/

Conference

ConferenceAnnual Meeting of the Austrian Society of the Biomedical Engineering 2021
Abbreviated titleÖGBMT 2021
Country/TerritoryAustria
CityGraz
Period30/09/211/10/21
Internet address

Fields of Expertise

  • Human- & Biotechnology

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