Human Enzymes for Organic Synthesis

Margit Winkler; Martina Geier; Steven P Hanlon; Bernd Nidetzky; Anton Glieder

doi:10.1002/anie.201800678

Human Enzymes for Organic Synthesis

Margit Winkler, Martina Geier, Steven P Hanlon, Bernd Nidetzky, Anton Glieder

Publikation: Beitrag in einer Fachzeitschrift › Review eines Fachbereichs (Review article) › Begutachtung

Abstract

Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

Originalsprache	englisch
Seiten (von - bis)	13406-13423
Seitenumfang	18
Fachzeitschrift	Angewandte Chemie - International Edition
Jahrgang	57
Ausgabenummer	41
DOIs	https://doi.org/10.1002/anie.201800678 https://doi.org/10.1002/anie.201800678
Publikationsstatus	Veröffentlicht - 2018

Fields of Expertise

Human- & Biotechnology

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1 Abgeschlossen

EU - ROBOX - Ausbau der industriellen Verwendung von Robusten Oxidativen Biokatalysten zur Umwandlung und Produktion von Alkoholen (ROBOX)
Glieder, A.
1/04/15 → 31/03/19
Projekt: Forschungsprojekt

Dieses zitieren

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abstract = "Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.",

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AU - Winkler, Margit

AU - Geier, Martina

AU - Hanlon, Steven P

AU - Nidetzky, Bernd

AU - Glieder, Anton

PY - 2018

Y1 - 2018

N2 - Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

AB - Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

U2 - 10.1002/anie.201800678

DO - 10.1002/anie.201800678

M3 - Review article

C2 - 29600541

SN - 1433-7851

VL - 57

SP - 13406

EP - 13423

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Human Enzymes for Organic Synthesis

Abstract

Fields of Expertise

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Projekte

EU - ROBOX - Ausbau der industriellen Verwendung von Robusten Oxidativen Biokatalysten zur Umwandlung und Produktion von Alkoholen (ROBOX)

Dieses zitieren