Human Enzymes for Organic Synthesis

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

Abstract

Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

Originalspracheenglisch
Seiten (von - bis)13406-13423
Seitenumfang18
FachzeitschriftAngewandte Chemie / International Edition
Jahrgang57
Ausgabenummer41
DOIs
PublikationsstatusVeröffentlicht - 2018

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Enzymes
Pharmaceutical Preparations
Xenobiotics
Metabolites
Metabolism
Chemical reactions
Catalysts

Fields of Expertise

  • Human- & Biotechnology

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Human Enzymes for Organic Synthesis. / Winkler, Margit; Geier, Martina; Hanlon, Steven P; Nidetzky, Bernd; Glieder, Anton.

in: Angewandte Chemie / International Edition , Jahrgang 57, Nr. 41, 2018, S. 13406-13423.

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

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AB - Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

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