Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Marcos Llusa; Stefan Mohr; Ramona Baumgartner; Amrit Paudel; Gerold Koscher; Johannes Khinast

doi:10.3109/03639045.2015.1135938

Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Marcos Llusa, Stefan Mohr, Ramona Baumgartner, Amrit Paudel, Gerold Koscher, Johannes Khinast^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a continuous extrusion process using a suspension. The challenges for feeding and the product homogeneity are both addressed.

Originalsprache	englisch
Seiten (von - bis)	1360-1364
Seitenumfang	4
Fachzeitschrift	Drug Development and Industrial Pharmacy
Jahrgang	42
Ausgabenummer	8
DOIs	https://doi.org/10.3109/03639045.2015.1135938
Publikationsstatus	Veröffentlicht - 2 Aug. 2016

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10.3109/03639045.2015.1135938

Dieses zitieren

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abstract = "Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a continuous extrusion process using a suspension. The challenges for feeding and the product homogeneity are both addressed.",

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