Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Marcos Llusa; Stefan Mohr; Ramona Baumgartner; Amrit Paudel; Gerold Koscher; Johannes Khinast

doi:10.3109/03639045.2015.1135938

Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Marcos Llusa, Stefan Mohr, Ramona Baumgartner, Amrit Paudel, Gerold Koscher, Johannes Khinast^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a continuous extrusion process using a suspension. The challenges for feeding and the product homogeneity are both addressed.

Original language	English
Pages (from-to)	1360-1364
Number of pages	4
Journal	Drug Development and Industrial Pharmacy
Volume	42
Issue number	8
DOIs	https://doi.org/10.3109/03639045.2015.1135938
Publication status	Published - 2 Aug 2016

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10.3109/03639045.2015.1135938

Cite this

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title = "Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion",

abstract = "Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a continuous extrusion process using a suspension. The challenges for feeding and the product homogeneity are both addressed.",

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AU - Mohr, Stefan

AU - Baumgartner, Ramona

AU - Paudel, Amrit

AU - Koscher, Gerold

AU - Khinast, Johannes

PY - 2016/8/2

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AB - Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a continuous extrusion process using a suspension. The challenges for feeding and the product homogeneity are both addressed.

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DO - 10.3109/03639045.2015.1135938

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