Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Amrit Paudel, Marcos Llusa, Stefan Mohr, Ramona Baumgartner, Gerold Koscher, Johannes Khinast

Research output: Contribution to journalArticle

Abstract

Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a continuous extrusion process using a suspension. The challenges for feeding and the product homogeneity are both addressed.
Original languageEnglish
Pages (from-to)1360-1364
Number of pages4
JournalDrug Development and Industrial Pharmacy
Publication statusPublished - 2 Aug 2016

Fingerprint Dive into the research topics of 'Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion'. Together they form a unique fingerprint.

Cite this