A MOF-based carrier for in situ dopamine delivery

Alessandra Pinna, Raffaele Ricco, Rossana Migheli, Gaia Rocchitta, Pier Andrea Serra, Paolo Falcaro, Luca Malfatti, Plinio Innocenzi

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing superparamagnetic nanoparticles to assemble a new class of biocompatible particles for magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release, dopamine protection from oxidative damage, long-term delivery and improved drug delivery cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and higher release efficiency than silica based carriers. The in vitro cytotoxicity at different MOF concentrations and sizes was assessed using PC12 cells as the neuronal cell model. The drug was directly uptaken into the PC12 cells avoiding possible side effects due to oxidation occurring in the extracellular environment.

Spracheenglisch
Seiten25664-25672
Seitenumfang9
FachzeitschriftRSC Advances
Jahrgang8
Ausgabennummer45
DOIs
StatusVeröffentlicht - 1 Jan 2018

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Dopamine
Drug delivery
Oxidation
Cytotoxicity
Silicon Dioxide
Pharmaceutical Preparations
Polymers
Silica
Nanoparticles
Crystals
Monitoring
Costs
N(1)-methyl-2-lysergic acid diethylamide

ASJC Scopus subject areas

  • !!Chemistry(all)
  • !!Chemical Engineering(all)

Dies zitieren

Pinna, A., Ricco, R., Migheli, R., Rocchitta, G., Serra, P. A., Falcaro, P., ... Innocenzi, P. (2018). A MOF-based carrier for in situ dopamine delivery. RSC Advances, 8(45), 25664-25672. https://doi.org/10.1039/c8ra04969f

A MOF-based carrier for in situ dopamine delivery. / Pinna, Alessandra; Ricco, Raffaele; Migheli, Rossana; Rocchitta, Gaia; Serra, Pier Andrea; Falcaro, Paolo; Malfatti, Luca; Innocenzi, Plinio.

in: RSC Advances, Jahrgang 8, Nr. 45, 01.01.2018, S. 25664-25672.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Pinna, A, Ricco, R, Migheli, R, Rocchitta, G, Serra, PA, Falcaro, P, Malfatti, L & Innocenzi, P 2018, 'A MOF-based carrier for in situ dopamine delivery', RSC Advances, Jg. 8, Nr. 45, S. 25664-25672. https://doi.org/10.1039/c8ra04969f
Pinna A, Ricco R, Migheli R, Rocchitta G, Serra PA, Falcaro P et al. A MOF-based carrier for in situ dopamine delivery. RSC Advances. 2018 Jan 1;8(45):25664-25672. https://doi.org/10.1039/c8ra04969f
Pinna, Alessandra ; Ricco, Raffaele ; Migheli, Rossana ; Rocchitta, Gaia ; Serra, Pier Andrea ; Falcaro, Paolo ; Malfatti, Luca ; Innocenzi, Plinio. / A MOF-based carrier for in situ dopamine delivery. in: RSC Advances. 2018 ; Jahrgang 8, Nr. 45. S. 25664-25672.
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