A MOF-based carrier for in situ dopamine delivery

Alessandra Pinna, Raffaele Ricco, Rossana Migheli, Gaia Rocchitta, Pier Andrea Serra, Paolo Falcaro, Luca Malfatti, Plinio Innocenzi

Research output: Contribution to journalArticleResearchpeer-review

Abstract

MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing superparamagnetic nanoparticles to assemble a new class of biocompatible particles for magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release, dopamine protection from oxidative damage, long-term delivery and improved drug delivery cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and higher release efficiency than silica based carriers. The in vitro cytotoxicity at different MOF concentrations and sizes was assessed using PC12 cells as the neuronal cell model. The drug was directly uptaken into the PC12 cells avoiding possible side effects due to oxidation occurring in the extracellular environment.

Original languageEnglish
Pages (from-to)25664-25672
Number of pages9
JournalRSC Advances
Volume8
Issue number45
DOIs
Publication statusPublished - 1 Jan 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    Pinna, A., Ricco, R., Migheli, R., Rocchitta, G., Serra, P. A., Falcaro, P., ... Innocenzi, P. (2018). A MOF-based carrier for in situ dopamine delivery. RSC Advances, 8(45), 25664-25672. https://doi.org/10.1039/c8ra04969f