A DNA origami plasmonic sensor with environment-independent read-out

Valentina Masciotti, Luca Piantanida, Denys Naumenko, Heinz Amenitsch, Mattia Fanetti, Matjaž Valant, Dongsheng Lei, Gang Ren, Marco Lazzarino

Research output: Contribution to journalArticleResearchpeer-review

Abstract

DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal, respectively. However, its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place, such as pressure, viscosity and any other unspecific interaction other than the desired target recognition. Here we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration, which is transduced in a change of its plasmonic properties, upon interaction with a specific DNA target. We investigated its response when analyzed in three different media: aqueous solution, solid support and viscous gel. We show that, once a conformational variation is produced, it remains unaffected by the subsequent physical interactions with the environment. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)2900-2907
Number of pages8
JournalNano Research
Volume12
Issue number11
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

DNA
Sensors
Drug delivery
Biocompatibility
Gold
Contrast Media
Conformations
Scalability
Gels
Viscosity
Nanoparticles
Pharmaceutical Preparations

Keywords

  • DNA origami
  • gold nanoparticle
  • molecular detection
  • plasmonic sensor

ASJC Scopus subject areas

  • Materials Science(all)
  • Electrical and Electronic Engineering

Fields of Expertise

  • Advanced Materials Science
  • Human- & Biotechnology

Cite this

Masciotti, V., Piantanida, L., Naumenko, D., Amenitsch, H., Fanetti, M., Valant, M., ... Lazzarino, M. (2019). A DNA origami plasmonic sensor with environment-independent read-out. Nano Research, 12(11), 2900-2907. https://doi.org/10.1007/s12274-019-2535-0

A DNA origami plasmonic sensor with environment-independent read-out. / Masciotti, Valentina; Piantanida, Luca; Naumenko, Denys; Amenitsch, Heinz; Fanetti, Mattia; Valant, Matjaž; Lei, Dongsheng; Ren, Gang; Lazzarino, Marco.

In: Nano Research, Vol. 12, No. 11, 01.11.2019, p. 2900-2907.

Research output: Contribution to journalArticleResearchpeer-review

Masciotti, V, Piantanida, L, Naumenko, D, Amenitsch, H, Fanetti, M, Valant, M, Lei, D, Ren, G & Lazzarino, M 2019, 'A DNA origami plasmonic sensor with environment-independent read-out' Nano Research, vol. 12, no. 11, pp. 2900-2907. https://doi.org/10.1007/s12274-019-2535-0
Masciotti, Valentina ; Piantanida, Luca ; Naumenko, Denys ; Amenitsch, Heinz ; Fanetti, Mattia ; Valant, Matjaž ; Lei, Dongsheng ; Ren, Gang ; Lazzarino, Marco. / A DNA origami plasmonic sensor with environment-independent read-out. In: Nano Research. 2019 ; Vol. 12, No. 11. pp. 2900-2907.
@article{0c89fdca1cf1498caf0b85bc7b789cf2,
title = "A DNA origami plasmonic sensor with environment-independent read-out",
abstract = "DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal, respectively. However, its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place, such as pressure, viscosity and any other unspecific interaction other than the desired target recognition. Here we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration, which is transduced in a change of its plasmonic properties, upon interaction with a specific DNA target. We investigated its response when analyzed in three different media: aqueous solution, solid support and viscous gel. We show that, once a conformational variation is produced, it remains unaffected by the subsequent physical interactions with the environment. [Figure not available: see fulltext.].",
keywords = "DNA origami, gold nanoparticle, molecular detection, plasmonic sensor",
author = "Valentina Masciotti and Luca Piantanida and Denys Naumenko and Heinz Amenitsch and Mattia Fanetti and Matjaž Valant and Dongsheng Lei and Gang Ren and Marco Lazzarino",
year = "2019",
month = "11",
day = "1",
doi = "10.1007/s12274-019-2535-0",
language = "English",
volume = "12",
pages = "2900--2907",
journal = "Nano Research",
issn = "1998-0124",
publisher = "Press of Tsinghua University",
number = "11",

}

TY - JOUR

T1 - A DNA origami plasmonic sensor with environment-independent read-out

AU - Masciotti, Valentina

AU - Piantanida, Luca

AU - Naumenko, Denys

AU - Amenitsch, Heinz

AU - Fanetti, Mattia

AU - Valant, Matjaž

AU - Lei, Dongsheng

AU - Ren, Gang

AU - Lazzarino, Marco

PY - 2019/11/1

Y1 - 2019/11/1

N2 - DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal, respectively. However, its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place, such as pressure, viscosity and any other unspecific interaction other than the desired target recognition. Here we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration, which is transduced in a change of its plasmonic properties, upon interaction with a specific DNA target. We investigated its response when analyzed in three different media: aqueous solution, solid support and viscous gel. We show that, once a conformational variation is produced, it remains unaffected by the subsequent physical interactions with the environment. [Figure not available: see fulltext.].

AB - DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal, respectively. However, its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place, such as pressure, viscosity and any other unspecific interaction other than the desired target recognition. Here we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration, which is transduced in a change of its plasmonic properties, upon interaction with a specific DNA target. We investigated its response when analyzed in three different media: aqueous solution, solid support and viscous gel. We show that, once a conformational variation is produced, it remains unaffected by the subsequent physical interactions with the environment. [Figure not available: see fulltext.].

KW - DNA origami

KW - gold nanoparticle

KW - molecular detection

KW - plasmonic sensor

UR - http://www.scopus.com/inward/record.url?scp=85074586970&partnerID=8YFLogxK

U2 - 10.1007/s12274-019-2535-0

DO - 10.1007/s12274-019-2535-0

M3 - Article

VL - 12

SP - 2900

EP - 2907

JO - Nano Research

JF - Nano Research

SN - 1998-0124

IS - 11

ER -