Abstract
DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal, respectively. However, its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place, such as pressure, viscosity and any other unspecific interaction other than the desired target recognition. Here we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration, which is transduced in a change of its plasmonic properties, upon interaction with a specific DNA target. We investigated its response when analyzed in three different media: aqueous solution, solid support and viscous gel. We show that, once a conformational variation is produced, it remains unaffected by the subsequent physical interactions with the environment. [Figure not available: see fulltext.].
Original language | English |
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Pages (from-to) | 2900-2907 |
Number of pages | 8 |
Journal | Nano Research |
Volume | 12 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1 Nov 2019 |
Keywords
- DNA origami
- gold nanoparticle
- molecular detection
- plasmonic sensor
ASJC Scopus subject areas
- General Materials Science
- Electrical and Electronic Engineering
Fields of Expertise
- Advanced Materials Science
- Human- & Biotechnology