A DNA origami plasmonic sensor with environment-independent read-out

Valentina Masciotti*, Luca Piantanida, Denys Naumenko, Heinz Amenitsch, Mattia Fanetti, Matjaž Valant, Dongsheng Lei, Gang Ren, Marco Lazzarino

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal, respectively. However, its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place, such as pressure, viscosity and any other unspecific interaction other than the desired target recognition. Here we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration, which is transduced in a change of its plasmonic properties, upon interaction with a specific DNA target. We investigated its response when analyzed in three different media: aqueous solution, solid support and viscous gel. We show that, once a conformational variation is produced, it remains unaffected by the subsequent physical interactions with the environment. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)2900-2907
Number of pages8
JournalNano Research
Volume12
Issue number11
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • DNA origami
  • gold nanoparticle
  • molecular detection
  • plasmonic sensor

ASJC Scopus subject areas

  • Materials Science(all)
  • Electrical and Electronic Engineering

Fields of Expertise

  • Advanced Materials Science
  • Human- & Biotechnology

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