Description
Current research of the group focuses on elucidating the kinetic and chemical mechanisms of how enzymes of interest work; and the application of these enzymes in technology-relevant processes. Major interest is on oxidoreductive enzymes and enzymes that make glycosidic bonds. Enzyme reaction engineering and stabilisation of enzyme activity are important components of technology-oriented research.
| Status | Active |
|---|---|
| Effective start/end date | 1/01/02 → … |
Related content
Research Outputs
Role of Phe-114 in substrate specificity of Candida tenuis xylose reductase (AKR2B5)
Research output: Contribution to journal › Article › Research › peer-review
Optimization of an innovative hollow-fiber process to produce lactose-reduced skim milk.
Research output: Contribution to journal › Article › Research › peer-review
Structural and functional characterization of recombinant fungal trehalose phosphorylase from Schizophyllum commune
Research output: Contribution to conference › Poster › Research
The family of long-chain mannitol dehydrogenases brought into focus.
Research output: Contribution to conference › Poster › Research
Structure-function relationships for xylose reductase from the yeast Candida tenuis.
Research output: Contribution to conference › Poster › Research
The xylose reductase (AKR2B5) structure: homology and divergence from other aldo-keto reductases and opportunities for protein engineering.
Research output: Contribution to journal › Article › Research › peer-review
Candida tenuis Xylose reductase (AKR2B5) utilizes different catalytic mechanisms for NADH-dependent carbonyl group reduction in aldehyde and quinone substrates
Research output: Contribution to conference › Poster › Research
Structure-guided engineering of the coenzyme specificity of Pseudomonas fluorescens mannitol 2-dehydrogenase to enable efficient utilization of NAD(H) and NADP(H)
Research output: Contribution to journal › Article › Research › peer-review
Electrostatic stabilization in alcohol dehydrogenase mechanisms: the oxyanion hole of D-mannitol 2-dehydrogenase from Pseudomonas fluorescens is a novel structural motif that facilitates the catalytic step of hydride transfer
Research output: Contribution to conference › Poster › Research
The reaction mechanism of D-mannitol 2-dehydrogenase from Pseudomonas fluorescens (PsM2DH) reveals convergent evolution of two alcohol dehydrogenase superfamilies.
Research output: Contribution to conference › Poster › Research
Structural and functional characterization of recombinant fungal trehalose phosphorylase from Schizophyllum commune
Research output: Contribution to conference › Poster › Research
The structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases.
Research output: Contribution to journal › Article › Research › peer-review
Tyr-51 is the proton donor–acceptor for NAD(H)-dependent interconversion of xylose and xylitol by Candida tenuis xylose reductase (AKR2B5)
Research output: Contribution to journal › Article › Research › peer-review
Mechanism and specificity of Candida tenuis xylose reductase (AKR2B5).
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
On the role of Bronsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase.
Research output: Contribution to journal › Article › Research › peer-review
Novel Chemo-Enzymatic Mimic of Hydrogen Peroxide-Forming NAD(P)H Oxidase for Efficient Regeneration of NAD+ and NADP+
Research output: Contribution to journal › Article › Research › peer-review
Glyco-Biotechnology. Oxidoreductases.
Research output: Contribution to conference › (Old data) Lecture or Presentation › Research
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu-154->Cys forms of yeast xylitol dehydrogenase
Research output: Contribution to journal › Article › Research › peer-review
Characterization of recombinant Aspergillus fumigatus mannitol-1-phosphate 5-dehydrogenase and its application for the stereoselective synthesis of protio and deuterio forms of D-mannitol 1-phosphate
Research output: Contribution to journal › Article › Research › peer-review
Projects
A2b Enzyme Stability
Project: Research area
A2a Biotechnology of Renewable Resources
Project: Research area
A2e Glyco - Biotechnology
Project: Research area
A2d Oxidative Enzymes and Biotransformations
Project: Research area
A2c Structure-Function Relationships of NAD(P)H - Dependent Dehydrogenases
Project: Research area