Abstract
From an easily available partially protected formal derivative of 1-deoxymannojirimycin, by hydroxymethyl chain-branching and further elaboration, lipophilic analogs of the powerful β-d-galactosidase inhibitor 4-epi-isofagomine have become available. New compounds exhibit improved inhibitory activities comparable to benchmark compound NOEV (N-octyl-epi-valienamine) and may serve as leads towards improved and more selective pharmacological chaperones for GM1-gangliosidosis.
Originalsprache | englisch |
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Seiten (von - bis) | 1438-1442 |
Seitenumfang | 5 |
Fachzeitschrift | Bioorganic & Medicinal Chemistry Letters |
Jahrgang | 26 |
Ausgabenummer | 5 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2016 |
Schlagwörter
- imino alditol prepn isofagomine GM1 gangliosidosis galactosidase inhibitor human