TY - JOUR
T1 - Interplay of protein corona and immune cells controls blood residency of liposomes
AU - Giulimondi, Francesca
AU - Digiacomo, Luca
AU - Pozzi, Daniela
AU - Palchetti, Sara
AU - Vulpis, Elisabetta
AU - Capriotti, Anna Laura
AU - Chiozzi, Riccardo Zenezini
AU - Laganà, Aldo
AU - Amenitsch, Heinz
AU - Masuelli, Laura
AU - Mahmoudi, Morteza
AU - Screpanti, Isabella
AU - Zingoni, Alessandra
AU - Caracciolo, Giulio
PY - 2019/12/1
Y1 - 2019/12/1
N2 - In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity. The liposome–protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.
AB - In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity. The liposome–protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.
UR - http://www.scopus.com/inward/record.url?scp=85070769064&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-11642-7
DO - 10.1038/s41467-019-11642-7
M3 - Article
C2 - 31417080
AN - SCOPUS:85070769064
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3686
ER -