Wrinkling of an Enteric Coating Induced by Vapor-Deposited Stimuli-Responsive Hydrogel Thin Films

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In this contribution, we report on the thin-film synthesis of a thermoresponsive polymer onto another polymer used as an enteric coating in drug applications. In particular, we deposit cross-linked poly(N-vinylcaprolactam) (pNVCL) thin films by initiated chemical vapor deposition (iCVD) onto spin-coated Eudragit (EUD) layers. Already upon iCVD synthesis, the layered structure starts to form wrinkles at a minimum iCVD thickness of 30 nm. By changing the EUD layer thickness and the amount of cross-linking used during iCVD, the morphology of the wrinkles is demonstrated to be readily tunable. Laterally, the double-layer structures vary in morphology from being ultrasmooth to exhibiting up to a 3.5 μm wrinkle wavelength. The surface roughness and, thus, the wrinkles' height can be tailored from below 1 nm up to 100 nm. From the resulting wavelength of wrinkles, an estimation of the elastic modulus of pNVCL proves its tunability over a wide range of values thanks to the iCVD process. This study elucidates an uncomplicated way to tune the wrinkles' morphology and, thus, the surface area of a system that can be employed in drug delivery applications. Hence, an enteric coating of EUD together with an iCVD-synthesized thermoresponsive thin film is proposed as a promising composite encapsulation layer to outperform established systems in terms of tunability of the response to multiple external stimuli.

Original languageEnglish
Pages (from-to)24165-24171
Number of pages7
JournalJournal of Physical Chemistry C
Volume123
Issue number39
DOIs
Publication statusPublished - 3 Oct 2019

Fingerprint

wrinkling
Hydrogel
Hydrogels
stimuli
Chemical vapor deposition
Vapors
vapor deposition
vapors
coatings
Thin films
Coatings
thin films
Polymers
drugs
Wavelength
polymers
synthesis
Drug delivery
Encapsulation
wavelengths

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

Cooperations

  • NAWI Graz

Cite this

Wrinkling of an Enteric Coating Induced by Vapor-Deposited Stimuli-Responsive Hydrogel Thin Films. / Muralter, Fabian; Coclite, Anna Maria; Werzer, Oliver.

In: Journal of Physical Chemistry C, Vol. 123, No. 39, 03.10.2019, p. 24165-24171.

Research output: Contribution to journalArticleResearchpeer-review

@article{f8e1e57f199c4b7f84e3213b218441b8,
title = "Wrinkling of an Enteric Coating Induced by Vapor-Deposited Stimuli-Responsive Hydrogel Thin Films",
abstract = "In this contribution, we report on the thin-film synthesis of a thermoresponsive polymer onto another polymer used as an enteric coating in drug applications. In particular, we deposit cross-linked poly(N-vinylcaprolactam) (pNVCL) thin films by initiated chemical vapor deposition (iCVD) onto spin-coated Eudragit (EUD) layers. Already upon iCVD synthesis, the layered structure starts to form wrinkles at a minimum iCVD thickness of 30 nm. By changing the EUD layer thickness and the amount of cross-linking used during iCVD, the morphology of the wrinkles is demonstrated to be readily tunable. Laterally, the double-layer structures vary in morphology from being ultrasmooth to exhibiting up to a 3.5 μm wrinkle wavelength. The surface roughness and, thus, the wrinkles' height can be tailored from below 1 nm up to 100 nm. From the resulting wavelength of wrinkles, an estimation of the elastic modulus of pNVCL proves its tunability over a wide range of values thanks to the iCVD process. This study elucidates an uncomplicated way to tune the wrinkles' morphology and, thus, the surface area of a system that can be employed in drug delivery applications. Hence, an enteric coating of EUD together with an iCVD-synthesized thermoresponsive thin film is proposed as a promising composite encapsulation layer to outperform established systems in terms of tunability of the response to multiple external stimuli.",
author = "Fabian Muralter and Coclite, {Anna Maria} and Oliver Werzer",
year = "2019",
month = "10",
day = "3",
doi = "10.1021/acs.jpcc.9b07340",
language = "English",
volume = "123",
pages = "24165--24171",
journal = "The journal of physical chemistry (Washington, DC) / C",
issn = "1932-7447",
publisher = "American Chemical Society",
number = "39",

}

TY - JOUR

T1 - Wrinkling of an Enteric Coating Induced by Vapor-Deposited Stimuli-Responsive Hydrogel Thin Films

AU - Muralter, Fabian

AU - Coclite, Anna Maria

AU - Werzer, Oliver

PY - 2019/10/3

Y1 - 2019/10/3

N2 - In this contribution, we report on the thin-film synthesis of a thermoresponsive polymer onto another polymer used as an enteric coating in drug applications. In particular, we deposit cross-linked poly(N-vinylcaprolactam) (pNVCL) thin films by initiated chemical vapor deposition (iCVD) onto spin-coated Eudragit (EUD) layers. Already upon iCVD synthesis, the layered structure starts to form wrinkles at a minimum iCVD thickness of 30 nm. By changing the EUD layer thickness and the amount of cross-linking used during iCVD, the morphology of the wrinkles is demonstrated to be readily tunable. Laterally, the double-layer structures vary in morphology from being ultrasmooth to exhibiting up to a 3.5 μm wrinkle wavelength. The surface roughness and, thus, the wrinkles' height can be tailored from below 1 nm up to 100 nm. From the resulting wavelength of wrinkles, an estimation of the elastic modulus of pNVCL proves its tunability over a wide range of values thanks to the iCVD process. This study elucidates an uncomplicated way to tune the wrinkles' morphology and, thus, the surface area of a system that can be employed in drug delivery applications. Hence, an enteric coating of EUD together with an iCVD-synthesized thermoresponsive thin film is proposed as a promising composite encapsulation layer to outperform established systems in terms of tunability of the response to multiple external stimuli.

AB - In this contribution, we report on the thin-film synthesis of a thermoresponsive polymer onto another polymer used as an enteric coating in drug applications. In particular, we deposit cross-linked poly(N-vinylcaprolactam) (pNVCL) thin films by initiated chemical vapor deposition (iCVD) onto spin-coated Eudragit (EUD) layers. Already upon iCVD synthesis, the layered structure starts to form wrinkles at a minimum iCVD thickness of 30 nm. By changing the EUD layer thickness and the amount of cross-linking used during iCVD, the morphology of the wrinkles is demonstrated to be readily tunable. Laterally, the double-layer structures vary in morphology from being ultrasmooth to exhibiting up to a 3.5 μm wrinkle wavelength. The surface roughness and, thus, the wrinkles' height can be tailored from below 1 nm up to 100 nm. From the resulting wavelength of wrinkles, an estimation of the elastic modulus of pNVCL proves its tunability over a wide range of values thanks to the iCVD process. This study elucidates an uncomplicated way to tune the wrinkles' morphology and, thus, the surface area of a system that can be employed in drug delivery applications. Hence, an enteric coating of EUD together with an iCVD-synthesized thermoresponsive thin film is proposed as a promising composite encapsulation layer to outperform established systems in terms of tunability of the response to multiple external stimuli.

UR - http://www.scopus.com/inward/record.url?scp=85072819322&partnerID=8YFLogxK

U2 - 10.1021/acs.jpcc.9b07340

DO - 10.1021/acs.jpcc.9b07340

M3 - Article

VL - 123

SP - 24165

EP - 24171

JO - The journal of physical chemistry (Washington, DC) / C

JF - The journal of physical chemistry (Washington, DC) / C

SN - 1932-7447

IS - 39

ER -