Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

Aleš Doliška, Volker Ribitsch, Karin Stana Kleinschek, Simona Strnad

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.

Original languageEnglish
Pages (from-to)246-255
Number of pages10
JournalCarbohydrate Polymers
Volume93
Issue number1
DOIs
Publication statusPublished - 1 Mar 2013
Externally publishedYes

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Keywords

  • Adsorption
  • Fibrinogen
  • Haemocompatibility
  • Modelling
  • QCM-D

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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