Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

Aleš Doliška; Volker Ribitsch; Karin Stana Kleinschek; Simona Strnad

doi:10.1016/j.carbpol.2012.02.075

Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

Aleš Doliška^*, Volker Ribitsch, Karin Stana Kleinschek, Simona Strnad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.

Original language	English
Pages (from-to)	246-255
Number of pages	10
Journal	Carbohydrate Polymers
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/j.carbpol.2012.02.075
Publication status	Published - 1 Mar 2013
Externally published	Yes

Keywords

Adsorption
Fibrinogen
Haemocompatibility
Modelling
QCM-D

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2012.02.075

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title = "Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D",

abstract = "In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.",

keywords = "Adsorption, Fibrinogen, Haemocompatibility, Modelling, QCM-D",

author = "Ale{\v s} Doli{\v s}ka and Volker Ribitsch and {Stana Kleinschek}, Karin and Simona Strnad",

year = "2013",

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doi = "10.1016/j.carbpol.2012.02.075",

language = "English",

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T1 - Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

AU - Doliška, Aleš

AU - Ribitsch, Volker

AU - Stana Kleinschek, Karin

AU - Strnad, Simona

PY - 2013/3/1

Y1 - 2013/3/1

N2 - In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.

AB - In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.

KW - Adsorption

KW - Fibrinogen

KW - Haemocompatibility

KW - Modelling

KW - QCM-D

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U2 - 10.1016/j.carbpol.2012.02.075

DO - 10.1016/j.carbpol.2012.02.075

M3 - Article

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AN - SCOPUS:84874655615

SN - 0144-8617

VL - 93

SP - 246

EP - 255

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

IS - 1

ER -

Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

Abstract

Keywords

ASJC Scopus subject areas

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