Vancomycin Loaded Glycerol Monooleate Liquid Crystalline Phases Modified with Surfactants

Spomenka Milak, Angela Chemelli, Otto Glatter, Andreas Zimmer*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The influence of two tuning agents, polyglycerol ester (PE) and triblock copolymer (TC), on the properties of glycerol monooleate (MO) liquid crystalline phase (LCP) was investigated to achieve the therapeutic concentration of vancomycin hydrochloride (VHCl) into the eye, topically during 60 min (1 h) and intravitreally during 2880 min (48 h). Different techniques were used to elucidate the impact of surfactants on the structure of the LCP: polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), and in vitro release tests I and II (simulating local and intravitreal application in the eye). The structure analysis by SAXS depicts that the inclusion of PE into the MO LCP provided partial transition of a hexagonal phase into a lamellar phase, and TC induced a partial transition of a hexagonal phase into an LCP which identification was difficult. The LCP modulated with PE and TC demonstrated different VHCl's release patterns and were evaluated by comparing our release data with the literature data. The comparison indicated that the LCP modulated with 30% w/w PE could be a promising VHCl delivery system intravitreally during 2880 min.

Original languageEnglish
Article number521
Pages (from-to)1-16
Number of pages16
JournalPharmaceutics
Volume12
Issue number6
DOIs
Publication statusPublished - 8 Jun 2020

Keywords

  • Encapsulation
  • Eye infections
  • Glycerol monooleate
  • Lyotropic mesophase
  • Polyglycerol ester
  • Triblock copolymer
  • Tuning agent
  • Vancomycin hydrochloride

ASJC Scopus subject areas

  • Pharmaceutical Science

Cooperations

  • NAWI Graz

Fingerprint Dive into the research topics of 'Vancomycin Loaded Glycerol Monooleate Liquid Crystalline Phases Modified with Surfactants'. Together they form a unique fingerprint.

  • Cite this