Abstract
The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMER TM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.
Original language | English |
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Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
Pages | 812-813 |
Number of pages | 2 |
ISBN (Electronic) | 9780692941836 |
Publication status | Published - 2020 |
Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences - Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017 |
Conference
Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences |
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Abbreviated title | MicrTAS 2017 |
Country/Territory | United States |
City | Savannah |
Period | 22/10/17 → 26/10/17 |
Fields of Expertise
- Human- & Biotechnology