Using oxygen-consuming thermoset plastics to generate hypoxic conditions in microfluidic devices for potential cell culture applications

D. Sticker, M. Rothbauer, J. Ehgartner, C. Steininger, W. Neuhaus, T. Mayr, T. Haraldsson, J.P. Kutter, P. Ertl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMER TM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Pages812-813
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences - Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicrTAS 2017
CountryUnited States
CitySavannah
Period22/10/1726/10/17

Fields of Expertise

  • Human- & Biotechnology

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    Sticker, D., Rothbauer, M., Ehgartner, J., Steininger, C., Neuhaus, W., Mayr, T., ... Ertl, P. (2020). Using oxygen-consuming thermoset plastics to generate hypoxic conditions in microfluidic devices for potential cell culture applications. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 812-813)