Use of AFM force spectroscopy for assessment of polymer response to conditions similar to the wound, during healing

Uroš Maver, Tina Maver*, Andrej Žnidaršič, Zdenka Peršin, Miran Gaberšček, Karin Stana-Kleinschek

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Force spectroscopy is a very promising technique for the evaluation of interactions within different environments. Knowledge about them is especially important during the design and preparation of those modern wound dressings in contact with a changing wound-environment over a prolonged time. Such exposure can cause a drastic decrease in the material's mechanical performance, and can lead to degradation, thus lowering the success of any healing process. Our study tries to establish a model system, which would enable us to assess the applicability of the mentioned technique for the evaluation of any interaction changes between polymer molecules and a chosen surface, after exposure to different environments. Our proposed experimental setup consists of two representative polymers, a model silicon surface, and two solutions of various pHs and ionic strengths, respectively. Within the chosen range of parameters, we are confident that we can prove the usefulness of force spectroscopy for further research into polymer suitability, for the development of novel wound dressings.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalMateriali in Tehnologije
Volume45
Issue number3
Publication statusPublished - 1 May 2011
Externally publishedYes

Keywords

  • AFM
  • Force spectroscopy
  • Model system
  • Polymer materials
  • Wound dressings

ASJC Scopus subject areas

  • Polymers and Plastics
  • Metals and Alloys

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