Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2% and 5% drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.
Original languageEnglish
Article number36:80
Pages (from-to)80
Number of pages11
JournalPharmaceutical research
Volume36
Issue number6
DOIs
Publication statusPublished - 2019

Keywords

  • dry powder inhaler (DPI)
  • inhalation
  • particle/material properties
  • powder blends
  • powder processing
  • Dry Powder Inhalers
  • Excipients/chemistry
  • Humans
  • Administration, Inhalation
  • Particle Size
  • Powders/chemistry
  • Drug Carriers/chemistry
  • Surface Properties
  • Chemistry, Pharmaceutical/methods
  • Albuterol/administration & dosage
  • Mannitol/chemistry
  • dry powder inhaler(DPI)

ASJC Scopus subject areas

  • Materials Science(all)
  • Pharmacology (medical)
  • Molecular Medicine
  • Biotechnology
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Fields of Expertise

  • Advanced Materials Science

Cite this

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate. / Zellnitz, Sarah; Pinto, Joana; Brunsteiner, Michael; Schröttner, Hartmuth; Khinast, Johannes; Paudel, Amrit.

In: Pharmaceutical research, Vol. 36, No. 6, 36:80, 2019, p. 80.

Research output: Contribution to journalArticleResearchpeer-review

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abstract = "Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2{\%} and 5{\%} drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.",
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AU - Khinast, Johannes

AU - Paudel, Amrit

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N2 - Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2% and 5% drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.

AB - Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2% and 5% drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.

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