Abstract
Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2% and 5% drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.
Original language | English |
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Article number | 36:80 |
Pages (from-to) | 80 |
Number of pages | 11 |
Journal | Pharmaceutical research |
Volume | 36 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- dry powder inhaler (DPI)
- inhalation
- particle/material properties
- powder blends
- powder processing
- Dry Powder Inhalers
- Excipients/chemistry
- Humans
- Administration, Inhalation
- Particle Size
- Powders/chemistry
- Drug Carriers/chemistry
- Surface Properties
- Chemistry, Pharmaceutical/methods
- Albuterol/administration & dosage
- Mannitol/chemistry
- dry powder inhaler(DPI)
ASJC Scopus subject areas
- Materials Science(all)
- Pharmacology (medical)
- Molecular Medicine
- Biotechnology
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry
Fields of Expertise
- Advanced Materials Science