Abstract
| Original language | English |
|---|---|
| Article number | 36:80 |
| Pages (from-to) | 80 |
| Number of pages | 11 |
| Journal | Pharmaceutical research |
| Volume | 36 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- dry powder inhaler (DPI)
- inhalation
- particle/material properties
- powder blends
- powder processing
- Dry Powder Inhalers
- Excipients/chemistry
- Humans
- Administration, Inhalation
- Particle Size
- Powders/chemistry
- Drug Carriers/chemistry
- Surface Properties
- Chemistry, Pharmaceutical/methods
- Albuterol/administration & dosage
- Mannitol/chemistry
- dry powder inhaler(DPI)
ASJC Scopus subject areas
- Materials Science(all)
- Pharmacology (medical)
- Molecular Medicine
- Biotechnology
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry
Fields of Expertise
- Advanced Materials Science
Cite this
Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate. / Zellnitz, Sarah; Pinto, Joana; Brunsteiner, Michael; Schröttner, Hartmuth; Khinast, Johannes; Paudel, Amrit.
In: Pharmaceutical research, Vol. 36, No. 6, 36:80, 2019, p. 80.Research output: Contribution to journal › Article › Research › peer-review
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TY - JOUR
T1 - Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate
AU - Zellnitz, Sarah
AU - Pinto, Joana
AU - Brunsteiner, Michael
AU - Schröttner, Hartmuth
AU - Khinast, Johannes
AU - Paudel, Amrit
PY - 2019
Y1 - 2019
N2 - Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2% and 5% drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.
AB - Purpose The performance of carrier-based dry powder inhaler(DPI) formulations can be critically impacted by interfacialinteractions driven by tribo-electrification. Therefore, theaim of the present work was to understand how distinct APIparticle characteristics affect the charging behaviour of blendsintended for DPI delivery.Methods Salbutamol sulphate (SBS) particles engineered viaspray-drying and jet milling were used as model APIs. Dmannitolwas selected as a model carrier. The materials werecharacterized concerning their different particle propertiesand their charge was analysed alone and in blends beforeand after flow over a stainless-steel pipe.Results The spray-dried SBS (amorphous and spherical)charged positively and to a higher extent than jet milled SBS(crystalline and acicular) that charged negatively and to a lowerextent. D-mannitol charged positively and to a higher extentthan the APIs. All drug-excipient blends charged negativelyand differences were found between the spray-dried andjet milled SBS blends at 2% and 5% drug loads.Conclusions It was demonstrated how distinct solid-states, particleshape, size and morphology as well as different water contentsof the different materials can affect tribo-charging. For theirbinary blends, the amount and nature of fines seem to governinter-particle contacts critically impacting charge evolution.
KW - dry powder inhaler (DPI)
KW - inhalation
KW - particle/material properties
KW - powder blends
KW - powder processing
KW - Dry Powder Inhalers
KW - Excipients/chemistry
KW - Humans
KW - Administration, Inhalation
KW - Particle Size
KW - Powders/chemistry
KW - Drug Carriers/chemistry
KW - Surface Properties
KW - Chemistry, Pharmaceutical/methods
KW - Albuterol/administration & dosage
KW - Mannitol/chemistry
KW - dry powder inhaler(DPI)
UR - http://www.scopus.com/inward/record.url?scp=85064182458&partnerID=8YFLogxK
U2 - 10.1007/s11095-019-2612-9
DO - 10.1007/s11095-019-2612-9
M3 - Article
VL - 36
SP - 80
JO - Pharmaceutical research
JF - Pharmaceutical research
SN - 0724-8741
IS - 6
M1 - 36:80
ER -