Towards environmentally acceptable synthesis of chiral α-hydroxy ketones: Via oxidase-lyase cascades

Sandy Schmidt, Tiago Pedroso De Almeida, Dörte Rother, Frank Hollmann

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a "green" biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

Original languageEnglish
Pages (from-to)1226-1229
Number of pages4
JournalGreen chemistry
Volume19
Issue number5
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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