TY - JOUR
T1 - Towards applications of bioentities@MOFs in biomedicine
AU - Velásquez-Hernández, Miriam de J.
AU - Linares-Moreau, Mercedes
AU - Astria, Efwita
AU - Carraro, Francesco
AU - Alyami, Mram Z.
AU - Khashab, Niveen M.
AU - Sumby, Christopher J.
AU - Doonan, Christian J.
AU - Falcaro, Paolo
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2021/2/15
Y1 - 2021/2/15
N2 - Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged as novel biocomposites for application to drug delivery, biosensing, biospecimen preservation, and cell and virus manipulation. The integration of biological entities into MOF matrices generates MOF biocomposites with functional characteristics that cannot be observed in the separate components, such as enhanced chemical and thermal stability, resistance to proteases, MOF-conferred selectivity, and controlled release. In this review, we will discuss these functional properties and applications of the biocomposites obtained by the encapsulation of (i) proteins, (ii) carbohydrates, (iii) nucleic acids, and (iv) viruses or cells in a MOF matrix. Finally, we review the post functionalization of MOF-based drug carriers with lipids as a potential route to enhance the dispersion, stability in biological fluids, and blood circulation time of MOF-based drug delivery systems.
AB - Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged as novel biocomposites for application to drug delivery, biosensing, biospecimen preservation, and cell and virus manipulation. The integration of biological entities into MOF matrices generates MOF biocomposites with functional characteristics that cannot be observed in the separate components, such as enhanced chemical and thermal stability, resistance to proteases, MOF-conferred selectivity, and controlled release. In this review, we will discuss these functional properties and applications of the biocomposites obtained by the encapsulation of (i) proteins, (ii) carbohydrates, (iii) nucleic acids, and (iv) viruses or cells in a MOF matrix. Finally, we review the post functionalization of MOF-based drug carriers with lipids as a potential route to enhance the dispersion, stability in biological fluids, and blood circulation time of MOF-based drug delivery systems.
KW - Biobanking
KW - Biocomposites
KW - Biomacromolecules
KW - Biosensing
KW - Drug delivery
KW - MOFs
UR - http://www.scopus.com/inward/record.url?scp=85097908626&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2020.213651
DO - 10.1016/j.ccr.2020.213651
M3 - Review article
AN - SCOPUS:85097908626
SN - 0010-8545
VL - 429
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 213651
ER -