Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Reina Wada; Takashi Kumon; Robert Kourist; Hiromichi Ohta; Daisuke Uemura; Shosuke Yoshida; Kenji Miyamoto

doi:10.1016/j.tetlet.2013.01.080

Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Reina Wada, Takashi Kumon, Robert Kourist, Hiromichi Ohta, Daisuke Uemura, Shosuke Yoshida, Kenji Miyamoto^*

^*Corresponding author for this work

Institute of Molecular Biotechnology (6550)

Research output: Contribution to journal › Article › peer-review

Abstract

We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.

Original language	English
Pages (from-to)	1921-1923
Number of pages	3
Journal	Tetrahedron Letters
Volume	54
Issue number	15
DOIs	https://doi.org/10.1016/j.tetlet.2013.01.080
Publication status	Published - 2013

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title = "Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants",

abstract = "We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.",

author = "Reina Wada and Takashi Kumon and Robert Kourist and Hiromichi Ohta and Daisuke Uemura and Shosuke Yoshida and Kenji Miyamoto",

year = "2013",

doi = "10.1016/j.tetlet.2013.01.080",

language = "English",

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pages = "1921--1923",

journal = "Tetrahedron Letters",

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T1 - Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

AU - Wada, Reina

AU - Kumon, Takashi

AU - Kourist, Robert

AU - Ohta, Hiromichi

AU - Uemura, Daisuke

AU - Yoshida, Shosuke

AU - Miyamoto, Kenji

PY - 2013

Y1 - 2013

N2 - We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.

AB - We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.

U2 - 10.1016/j.tetlet.2013.01.080

DO - 10.1016/j.tetlet.2013.01.080

M3 - Article

SN - 0040-4039

VL - 54

SP - 1921

EP - 1923

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 15

ER -

Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Abstract

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