The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow

Georg Johannes Lichtenegger; Vitan Turšič; Hannes Kitzler; Klemens Obermaier; Johannes Khinast; Heidrun Gruber-Wölfler

doi:10.1002/cite.201600013

The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow

Georg Johannes Lichtenegger, Vitan Turšič, Hannes Kitzler, Klemens Obermaier, Johannes Khinast, Heidrun Gruber-Wölfler^*

^*Corresponding author for this work

Institute of Process and Particle Engineering (6690)

Research output: Contribution to journal › Article › peer-review

Abstract

The so-called plug & play reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. Its performance is demonstrated for two model processes: the production of acetylsalicylic acid with a fixed bed of commercial ion-exchange particles and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV-vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes.

Original language	English
Pages (from-to)	1518-1523
Journal	Chemie - Ingenieur - Technik
Volume	88
Issue number	10
DOIs	https://doi.org/10.1002/cite.201600013
Publication status	Published - 27 Jul 2016

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Advanced Materials Science

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10.1002/cite.201600013

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title = "The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow",

abstract = "The so-called plug & play reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. Its performance is demonstrated for two model processes: the production of acetylsalicylic acid with a fixed bed of commercial ion-exchange particles and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV-vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes.",

keywords = "Festbettreakot, kontinuierliche Synthese, Suzuki-Miyaura Reaktion",

author = "Lichtenegger, {Georg Johannes} and Vitan Tur{\v s}i{\v c} and Hannes Kitzler and Klemens Obermaier and Johannes Khinast and Heidrun Gruber-W{\"o}lfler",

year = "2016",

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doi = "10.1002/cite.201600013",

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AU - Lichtenegger, Georg Johannes

AU - Turšič, Vitan

AU - Kitzler, Hannes

AU - Obermaier, Klemens

AU - Khinast, Johannes

AU - Gruber-Wölfler, Heidrun

PY - 2016/7/27

Y1 - 2016/7/27

N2 - The so-called plug & play reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. Its performance is demonstrated for two model processes: the production of acetylsalicylic acid with a fixed bed of commercial ion-exchange particles and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV-vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes.

AB - The so-called plug & play reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. Its performance is demonstrated for two model processes: the production of acetylsalicylic acid with a fixed bed of commercial ion-exchange particles and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV-vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes.

KW - Festbettreakot

KW - kontinuierliche Synthese

KW - Suzuki-Miyaura Reaktion

U2 - 10.1002/cite.201600013

DO - 10.1002/cite.201600013

M3 - Article

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EP - 1523

JO - Chemie - Ingenieur - Technik

JF - Chemie - Ingenieur - Technik

IS - 10

ER -

The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow

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