Temperature-induced modulation of the electrophysiological behavior of A549 lung cancer cells

Research output: Contribution to journalArticlepeer-review


Cancer cells typically exhibit altered ion channel expression and membrane potential, wich plays an important role in various processes such as proliferation or apoptosis Hence, therapeutic strategies that modulate ion channel activity or shift the membrane potential prove to be promising for cancer therapy. Since temperature significantly affects ion channel function, deviation from normal body temperture might provide akey factor in electrophysiological progression. In this pilot study, we focused on a first insight into the temperature-induced modulation of A549 cells using an automated patch clamp system. Measurements of 14 cells at hypo-, normo- and hypertermia were accomplished to investigate the temperature-dependent electophysiological behavior. The results revealed that both, temperatures below and above normal body temperature affect the current and potential of A549 cells. In hyperthermia the potential tends to more hyperpolarized values, while conversely, in hypothermic conditions we observer mainly a lower current reponse and thus a depolarization of the membrane potential.
Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalCurrent Directions in Biomedical Engineering
Issue number2
Publication statusPublished - 1 Aug 2022

Fields of Expertise

  • Human- & Biotechnology


Dive into the research topics of 'Temperature-induced modulation of the electrophysiological behavior of A549 lung cancer cells'. Together they form a unique fingerprint.

Cite this