Temperature Dependency of T1 Relaxation Time in Unfixed and Fixed Human Brain Tissue

C Birkl; C Langkammer; J Haybaeck; C Ernst; R Stollberger; F Fazekas; S Ropele

doi:10.1515/bmt-2013-4290

Temperature Dependency of T1 Relaxation Time in Unfixed and Fixed Human Brain Tissue

C Birkl, C Langkammer, J Haybaeck, C Ernst, R Stollberger, F Fazekas, S Ropele

Institute of Biomedical Imaging (7170)

Research output: Contribution to journal › Article › peer-review

Abstract

MR relaxation times of most tissues are ex-pected to depend on temperature which can impact find-ings in post mortem MRI or MRI based thermometry. The purpose of this study was to investigate the exact tem-perature dependency of the T1 relaxation in different structures in unfixed and fixed human brain samples. Following autopsy, coronal brain slices from five de-ceased subjects underwent MRI at 3T in a temperature range between 4°C and 37°C. T1 showed a linear depend-ency on temperature with the highest temperature coeffi-cient in the cortex (17 ms/°C) and the lowest in the white matter (3ms/°C). The fixation of the tissue lowered T1 and additionally the temperature coefficient in all regions investigated. The temperature coefficients obtained in this study serve as reference for thermometry and for correct-ing quantitative post mortem MRI.

Original language	English
Number of pages	2
Journal	Biomedical Engineering - Biomedizinische Technik
Volume	58
Issue number	Suppl. 1
DOIs	https://doi.org/10.1515/bmt-2013-4290
Publication status	Published - 2013

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title = "Temperature Dependency of T1 Relaxation Time in Unfixed and Fixed Human Brain Tissue",

abstract = "MR relaxation times of most tissues are ex-pected to depend on temperature which can impact find-ings in post mortem MRI or MRI based thermometry. The purpose of this study was to investigate the exact tem-perature dependency of the T1 relaxation in different structures in unfixed and fixed human brain samples. Following autopsy, coronal brain slices from five de-ceased subjects underwent MRI at 3T in a temperature range between 4°C and 37°C. T1 showed a linear depend-ency on temperature with the highest temperature coeffi-cient in the cortex (17 ms/°C) and the lowest in the white matter (3ms/°C). The fixation of the tissue lowered T1 and additionally the temperature coefficient in all regions investigated. The temperature coefficients obtained in this study serve as reference for thermometry and for correct-ing quantitative post mortem MRI.",

keywords = "Journal Article, MRI, Biomedical Engineering",

author = "C Birkl and C Langkammer and J Haybaeck and C Ernst and R Stollberger and F Fazekas and S Ropele",

year = "2013",

doi = "10.1515/bmt-2013-4290",

language = "English",

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TY - JOUR

T1 - Temperature Dependency of T1 Relaxation Time in Unfixed and Fixed Human Brain Tissue

AU - Birkl, C

AU - Langkammer, C

AU - Haybaeck, J

AU - Ernst, C

AU - Stollberger, R

AU - Fazekas, F

AU - Ropele, S

PY - 2013

Y1 - 2013

N2 - MR relaxation times of most tissues are ex-pected to depend on temperature which can impact find-ings in post mortem MRI or MRI based thermometry. The purpose of this study was to investigate the exact tem-perature dependency of the T1 relaxation in different structures in unfixed and fixed human brain samples. Following autopsy, coronal brain slices from five de-ceased subjects underwent MRI at 3T in a temperature range between 4°C and 37°C. T1 showed a linear depend-ency on temperature with the highest temperature coeffi-cient in the cortex (17 ms/°C) and the lowest in the white matter (3ms/°C). The fixation of the tissue lowered T1 and additionally the temperature coefficient in all regions investigated. The temperature coefficients obtained in this study serve as reference for thermometry and for correct-ing quantitative post mortem MRI.

AB - MR relaxation times of most tissues are ex-pected to depend on temperature which can impact find-ings in post mortem MRI or MRI based thermometry. The purpose of this study was to investigate the exact tem-perature dependency of the T1 relaxation in different structures in unfixed and fixed human brain samples. Following autopsy, coronal brain slices from five de-ceased subjects underwent MRI at 3T in a temperature range between 4°C and 37°C. T1 showed a linear depend-ency on temperature with the highest temperature coeffi-cient in the cortex (17 ms/°C) and the lowest in the white matter (3ms/°C). The fixation of the tissue lowered T1 and additionally the temperature coefficient in all regions investigated. The temperature coefficients obtained in this study serve as reference for thermometry and for correct-ing quantitative post mortem MRI.

KW - Journal Article

KW - MRI

KW - Biomedical Engineering

U2 - 10.1515/bmt-2013-4290

DO - 10.1515/bmt-2013-4290

M3 - Article

C2 - 24042944

SN - 0013-5585

VL - 58

JO - Biomedical Engineering - Biomedizinische Technik

JF - Biomedical Engineering - Biomedizinische Technik

IS - Suppl. 1

ER -

Temperature Dependency of T1 Relaxation Time in Unfixed and Fixed Human Brain Tissue

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