In recent years, personalized healthcare has become increasingly popular in our society. Wearable devices started a trend for monitoring physical health parameters. The next evolution after wearable devices are Point-Of-Care (POC) devices, which provide more vital parameter analyses for everyone. The electrification of POC devices is required to simplify the process and to increase the accuracy of measurement results. In this work, we focus on POC devices in combination with smartphones. Of Ten, these devices are measuring and processing very sensitive data, which underlie a high privacy restriction. Therefore, it is required to provide an architecture and security issue analysis of POC devices. The outcome of this research contribution provides a sensitization for the requirement of enhanced security features. Especially, to fulfill the need for a power-Aware security concept for a POC system architecture, which underlies limited resources like power consumption.