STDP forms associations between memory traces in networks of spiking neurons

Christoph Pokorny, Matias J. Ison, Arjun Rao, Robert Legenstein, Wolfgang Maass, Christos Papadimitriou

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Memory traces and associations between them are fundamental for cognitive brain function. Neuron recordings suggest that distributed assemblies of neurons in the brain serve as memory traces for spatial information, real-world items, and concepts. However, there is conicting evidence regarding neural codes for associated memory traces. Some studies suggest the emergence of overlaps between assemblies during an association, while others suggest that the assemblies themselves remain largely unchanged and new assemblies emerge as neural codes for associated memory items. Here we study the
emergence of neural codes for associated memory items in a generic computational model of recurrent networks of spiking neurons with a data-constrained rule for spike-timingdependent plasticity (STDP). The model depends critically on two parameters, which control the excitability of neurons and the scale of initial synaptic weights. By modifying these two parameters, the model can reproduce both experimental data from the human brain on the fast formation of associations through emergent overlaps between assemblies, and rodent data where new neurons are recruited to encode the associated
memories. Hence our findings suggest that the brain can use both of these two neural codes for associations, and dynamically switch between them during consolidation.
Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalCerebral Cortex
Volume2019
Issue number00
DOIs
Publication statusPublished - 12 Aug 2019

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