TY - JOUR
T1 - Stable aqueous dispersions of bare and double layer functionalized superparamagnetic iron oxide nanoparticles for biomedical applications
AU - Markhulia, Jano
AU - Kekutia, Shalva
AU - Mikelashvili, Vladimer
AU - Almásy, László
AU - Saneblidze, Liana
AU - Tsertsvadze, Tamar
AU - Maisuradze, Nino
AU - Leladze, Nino
AU - Kriechbaum, Manfred
N1 - Funding Information:
This work was supported by Shota Rustaveli National Science Foundation of Georgia (SRNSFG) under GENIE project (Grant CARYS-19–976). The authors would like to acknowledge use of the Somapp Lab, a core facility supported by the Austrian Federal Ministry of Education, Science and Research, the Graz University of Technology, the University of Graz, and Anton Paar GmbH. The authors acknowledge the CERIC-ERIC Consortium for access to experimental facilities and financial support (Proposal no. 20177016).
Publisher Copyright:
© 2021 Jano Markhulia et al., published by Sciendo.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted the particular interest of scientists from various disciplines since their obtaining to the present day. The physicochemical and pharmacokinetic properties of SPIONs-containing magnetic nanofluids, and their applicability in biomedicine, largely depend on the stability of the colloidal system, particle size, size distribution, net magnetic moment, phase composition, and type and properties of stabilizers. Also, in some cases, when using magnetic nanoparticles for biomedical purposes, it is necessary that the stabilizing ligands of nanoparticles should not significantly change the magnetic properties. From this point of view, the preparation of stable colloidal systems containing bare iron oxide nanoparticles (BIONs) in water at physiological pH attracts particular attention and becomes increasingly popular in scientific circles. This study is focused on the development of the synthesis of aqueous suspensions of SPIONs stabilized with various organic molecules (oleic acid [OA] and poly(ethylene glycol) monooleate - with molecular weights 460 and 860) using a modified controlled chemical coprecipitation reaction, as well as stable nanofluids containing BIONs in an aqueous medium at neutral pH (near-physiological). The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy, small-angle x-ray scattering (SAXS), dynamic light scattering (DLS), electrophoretic light scattering (ELS), and Vibrating Sample Magnetometry.
AB - Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted the particular interest of scientists from various disciplines since their obtaining to the present day. The physicochemical and pharmacokinetic properties of SPIONs-containing magnetic nanofluids, and their applicability in biomedicine, largely depend on the stability of the colloidal system, particle size, size distribution, net magnetic moment, phase composition, and type and properties of stabilizers. Also, in some cases, when using magnetic nanoparticles for biomedical purposes, it is necessary that the stabilizing ligands of nanoparticles should not significantly change the magnetic properties. From this point of view, the preparation of stable colloidal systems containing bare iron oxide nanoparticles (BIONs) in water at physiological pH attracts particular attention and becomes increasingly popular in scientific circles. This study is focused on the development of the synthesis of aqueous suspensions of SPIONs stabilized with various organic molecules (oleic acid [OA] and poly(ethylene glycol) monooleate - with molecular weights 460 and 860) using a modified controlled chemical coprecipitation reaction, as well as stable nanofluids containing BIONs in an aqueous medium at neutral pH (near-physiological). The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy, small-angle x-ray scattering (SAXS), dynamic light scattering (DLS), electrophoretic light scattering (ELS), and Vibrating Sample Magnetometry.
KW - bare iron oxide nanoparticles
KW - ferrofluids
KW - oleic acid
KW - Poly (ethylene glycol) monooleate
KW - SPIONs
UR - http://www.scopus.com/inward/record.url?scp=85121321364&partnerID=8YFLogxK
U2 - 10.2478/msp-2021-0028
DO - 10.2478/msp-2021-0028
M3 - Article
AN - SCOPUS:85121321364
SN - 2083-1331
VL - 39
SP - 331
EP - 345
JO - Materials Science - Poland
JF - Materials Science - Poland
IS - 3
ER -