Solvent‐ and Catalyst‐Free Aza‐Michael Addition of Imidazoles and Related Heterocycles

Katharina Kodolitsch, Florian Gobec, Christian Slugovc*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

This work demonstrates the scope and limitations of the aza-Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent- and catalyst-free conditions. The reaction proceeds at 80 °C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been used in small excess. Workup only comprises evaporation of surplus Michael-acceptor, and no additional solvents are necessary for purifying the products.

Original languageEnglish
Pages (from-to)2973-2978
Number of pages6
JournalEuropean Journal of Organic Chemistry
Volume2020
Issue number19
DOIs
Publication statusPublished - 22 May 2020

Keywords

  • Aza-Michael reaction
  • Catalyst-free synthesis
  • Green chemistry
  • Heterocycles
  • Solvent-free synthesis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fields of Expertise

  • Advanced Materials Science

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