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Abstract
This work demonstrates the scope and limitations of the aza-Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent- and catalyst-free conditions. The reaction proceeds at 80 °C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been used in small excess. Workup only comprises evaporation of surplus Michael-acceptor, and no additional solvents are necessary for purifying the products.
| Original language | English |
|---|---|
| Pages (from-to) | 2973-2978 |
| Number of pages | 6 |
| Journal | European Journal of Organic Chemistry |
| Volume | 2020 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 22 May 2020 |
Keywords
- Aza-Michael reaction
- Catalyst-free synthesis
- Green chemistry
- Heterocycles
- Solvent-free synthesis
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
Fields of Expertise
- Advanced Materials Science
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Porous Materials @ Work
Klimant, I., Nidetzky, B., Coclite, A. M., Schennach, R., Sonderegger, B., Resel, R., Würschum, R., Amenitsch, H., Zojer, E., Bergmann, A., Falcaro, P., Borisov, S., Trimmel, G. & Slugovc, C.
1/07/18 → 31/03/22
Project: Research project