Sodium transients in an astrocyte

Kerstin Lenk; Aapo Tervonen; Jari Hyttinen

doi:10.3217/978-3-85125-826-4-03

Sodium transients in an astrocyte

Kerstin Lenk^*, Aapo Tervonen, Jari Hyttinen

^*Corresponding author for this work

Institute of Neural Engineering (7090)

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

Abstract

Astrocytes, a type of glial cells in the brain, are actively involved in neuronal information processing and memory formation. An astrocyte participates in neuronal activity by receiving neuro-transmitters, e.g., glutamate, from an adjacent pre-synapse. This leads to the propagation of astrocytic
intra- and intercellular calcium waves. In this study,we extend the computational model presented by Oschmann et al. (2017) to a finite element model of
single astrocytes, including a realistic 2D geometry and inositol 1,4,5-trisphosphate (IP3) and ion diffusion. Here, we conduct a parameter exploration of the sodium-calcium exchanger (NCX) and sodium-potassium-ATPase (NKA) rate constants. The calcium concentration directly depends on the amplitude
of the glutamate stimulus. However, the sodium concentration instead relates only to the sodium-potassium pump activity.

Original language	English
Title of host publication	Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021
Subtitle of host publication	ÖGBMT 2021
Editors	Gernot R. Müller-Putz, Christian Baumgartner
Place of Publication	Graz
Publisher	Verlag der Technischen Universität Graz
Pages	9-12
ISBN (Electronic)	978-3-85125-826-4
DOIs	https://doi.org/10.3217/978-3-85125-826-4-03
Publication status	Published - 2021
Event	Annual Meeting of the Austrian Society of the Biomedical Engineering 2021: ÖGBMT 2021 - Graz University of Technology, Graz, Austria Duration: 30 Sept 2021 → 1 Oct 2021 https://oegbmt2021.tugraz.at/

Conference

Conference	Annual Meeting of the Austrian Society of the Biomedical Engineering 2021
Abbreviated title	ÖGBMT 2021
Country/Territory	Austria
City	Graz
Period	30/09/21 → 1/10/21
Internet address	https://oegbmt2021.tugraz.at/

Fields of Expertise

Human- & Biotechnology

Access to Document

10.3217/978-3-85125-826-4-03Licence: CC BY 4.0

Cite this

Sodium transients in an astrocyte. / Lenk, Kerstin; Tervonen, Aapo; Hyttinen, Jari.
Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021: ÖGBMT 2021. ed. / Gernot R. Müller-Putz; Christian Baumgartner. Graz: Verlag der Technischen Universität Graz, 2021. p. 9-12.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

Lenk, K, Tervonen, A & Hyttinen, J 2021, Sodium transients in an astrocyte. in GR Müller-Putz & C Baumgartner (eds), Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021: ÖGBMT 2021. Verlag der Technischen Universität Graz, Graz, pp. 9-12, Annual Meeting of the Austrian Society of the Biomedical Engineering 2021, Graz, Austria, 30/09/21. https://doi.org/10.3217/978-3-85125-826-4-03

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