Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate

Martin Gericke, Aleš Doliška, Jan Stana, Tim Liebert, Thomas Heinze, Karin Stana-Kleinschek

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalMacromolecular Bioscience
Volume11
Issue number4
DOIs
Publication statusPublished - 8 Apr 2011
Externally publishedYes

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Keywords

  • Anticoagulant coatings
  • Blood compatibility
  • Cellulose sulfates
  • Chitosan
  • Layer-by-layer assemblies

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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