R1 dispersion contrast at high field with fast field-cycling MRI

Markus Bödenler*, Martina Basini, Maria Francesca Casula, Evrim Umut, Christian Gösweiner, Andreas Petrovic, Danuta Kruk, Hermann Scharfetter

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Contrast agents with a strong R1 dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R1 field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B0 field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation was successfully performed with selected iron oxide magnetic nanoparticles and comparison to FFC-NMR relaxometry measurements. Furthermore, we show proof-of-principle R1 dispersion imaging and demonstrate the capability of generating R1 dispersion contrast at high field with suppressed background signal. With the presented ready-to-use hardware setup it is possible to investigate MRI contrast agents with a strong R1 dispersion at a field strength of 3 T.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of magnetic resonance
Volume290
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Contrast agent
  • Delta relaxation enhanced MR
  • Dispersion
  • Fast field-cycling
  • MRI
  • Quadrupole relaxation enhancement

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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