Recovery of cis,cis-muconic acid from organic phase after reactive extraction

Jannick Gorden, Tim Zeiner, Gabriele Sadowski, Christoph Brandenbusch

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Reactive extraction has been shown as an applicable first step in the downstream processing for the recovery of dicarboxylic acids from aqueous solutions, leading to yields of XRE = 0.95 ± 0.05 for cis,cis-muconic acid. A next step towards a downstream processing concept is the examination of strategies to recover the dicarboxylic acid from the organic phase. A reasonable strategy has to lead to high yields and allow for a recycle of the organic phase for further reactive extraction steps. This work presents two recovery strategies for the cis,cis-muconic acid after reactive extraction. A pH-shift uses the strong pH dependency of the reactive extraction itself. A buffered aqueous phase as re-extraction phase leads to a yield of XREEX = 0.99 ± 0.080 at pH > 7. The second approach is the addition of water soluble amines as an additional reactive component. A complex of water soluble amines and the acid is re-extracted into an aqueous phase. Propylamine showed the best performance (XREEX = 1 ± 0.069) of all water soluble amines investigated. An analysis of the distribution behavior of the water soluble amines showed that a recycle of the organic phase for further reactive extraction steps is feasible for both strategies. The results allow for a further development of an in situ downstream processing concept for biocatalytic produced dicarboxylic acids.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalSeparation and purification technology
Volume169
DOIs
Publication statusPublished - 1 Sep 2016

Fingerprint

Recovery
Dicarboxylic Acids
Amines
Acids
Water
In situ processing
Propylamines
Processing
muconic acid

Keywords

  • cis,cis-muconic acid
  • Downstream processing
  • Re-extraction
  • Reactive extraction
  • Recovery

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

Cite this

Recovery of cis,cis-muconic acid from organic phase after reactive extraction. / Gorden, Jannick; Zeiner, Tim; Sadowski, Gabriele; Brandenbusch, Christoph.

In: Separation and purification technology, Vol. 169, 01.09.2016, p. 1-8.

Research output: Contribution to journalArticleResearchpeer-review

Gorden, Jannick ; Zeiner, Tim ; Sadowski, Gabriele ; Brandenbusch, Christoph. / Recovery of cis,cis-muconic acid from organic phase after reactive extraction. In: Separation and purification technology. 2016 ; Vol. 169. pp. 1-8.
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