@article{503153dc98e34c9ca0a2bfa5878651f5,
title = "Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes",
abstract = "Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover a systematic assessment and discuss the spray-drying of diverse protein pharmaceuticals and excipients included therein, solvent systems applicable to these formulations, equipment used and, respective process parameters. Further, key quality aspects of spray-dried protein solids are discussed. Based on the overall trends, we present a concise perspective into the future of protein pharmaceuticals spray-drying.",
keywords = "antibody, drug products, protein pharmaceuticals, protein powder, solvents, spray-drying, vaccine",
author = "Pinto, {Joana T.} and Eva Faulhammer and Johanna Dieplinger and Michael Dekner and Christian Makert and Marco Nieder and Amrit Paudel",
note = "Funding Information: This work was funded through the Austrian COMET?Competence Centres for Excellent Technologies programme including Baxter AG (part of Takeda) and Maag Germany GmbH as project partners. The COMET programme is operated by the Austrian Research Promotion Agency (FFG) on behalf of the Federal Ministry for Transport, Innovation and Technology (BMVIT) and the Federal Ministry for Digital and Economic Affairs (BMDW). Our projects are also funded by Land Steiermark and the Styrian Business Development Agency (SFG). Publisher Copyright: {\textcopyright} 2021 Research Center Pharmaceutical Engineering GmbH Baxter AG Maag Germay GmbH. Published with license by Taylor and Francis Group, LLC.",
year = "2021",
doi = "10.1080/07373937.2021.1903032",
language = "English",
volume = "39",
pages = "1415--1446",
journal = "Drying Technology",
issn = "0737-3937",
publisher = "Taylor and Francis Ltd.",
number = "11",
}
