Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

Joana T. Pinto, Eva Faulhammer, Johanna Dieplinger, Michael Dekner, Christian Makert, Marco Nieder, Amrit Paudel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover a systematic assessment and discuss the spray-drying of diverse protein pharmaceuticals and excipients included therein, solvent systems applicable to these formulations, equipment used and, respective process parameters. Further, key quality aspects of spray-dried protein solids are discussed. Based on the overall trends, we present a concise perspective into the future of protein pharmaceuticals spray-drying.

Original languageEnglish
Pages (from-to)1415-1446
Number of pages32
JournalDrying technology
Volume39
Issue number11
DOIs
Publication statusPublished - 2021

Keywords

  • antibody
  • drug products
  • protein pharmaceuticals
  • protein powder
  • solvents
  • spray-drying
  • vaccine

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Physical and Theoretical Chemistry

Fingerprint

Dive into the research topics of 'Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes'. Together they form a unique fingerprint.

Cite this