Physicochemical properties and bioactivity of a novel class of cellulosics: 6-deoxy-6-amino cellulose sulfate

The physicochemical behavior with emphasis on the charging behavior of 6-deoxy-6-(2-(bis(2-aminoethyl)aminoethyl-amino) cellulose sulfate (BAECS) with degree of substitution (DS) of 1.31 (sulfate moieties) and 0.71 (amino moieties) and of 6-deoxy-6-(2-aminoethyl) cellulose sulfate (AECS, DS _Sulf = 1.41, DS _DAE = 0.85, DS _Tosyl ≈0.09) is studied by using several types of titrations. The amounts of protonated amino groups determined by conductometric titration are 4.02 and 2.53 mmol g ^-1 for BAECS and AECS, respectively. The amino groups are fully deprotonated at pH ≥ 11, whereas the sulfate moieties determined by polyelectrolyte titration are fully dissociated at this pH value. Furthermore, studies on the antimicrobial and antithrombogenetic efficiencies of the samples are carried out.