Physicochemical properties and bioactivity of a novel class of cellulosics: 6-deoxy-6-amino cellulose sulfate

Taha Genco, Lidija Fras Zemljič, Matej Bračič, Karin Stana-Kleinschek, Thomas Heinze*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The physicochemical behavior with emphasis on the charging behavior of 6-deoxy-6-(2-(bis(2-aminoethyl)aminoethyl-amino) cellulose sulfate (BAECS) with degree of substitution (DS) of 1.31 (sulfate moieties) and 0.71 (amino moieties) and of 6-deoxy-6-(2-aminoethyl) cellulose sulfate (AECS, DS Sulf = 1.41, DS DAE = 0.85, DS Tosyl ≈0.09) is studied by using several types of titrations. The amounts of protonated amino groups determined by conductometric titration are 4.02 and 2.53 mmol g -1 for BAECS and AECS, respectively. The amino groups are fully deprotonated at pH ≥ 11, whereas the sulfate moieties determined by polyelectrolyte titration are fully dissociated at this pH value. Furthermore, studies on the antimicrobial and antithrombogenetic efficiencies of the samples are carried out.

Original languageEnglish
Pages (from-to)539-548
Number of pages10
JournalMacromolecular chemistry and physics
Volume213
Issue number5
DOIs
Publication statusPublished - 16 Mar 2012
Externally publishedYes

Keywords

  • amino cellulose sulfate
  • ampholyte
  • bioactivity
  • cellulose
  • polyelectrolyte
  • polysaccharide
  • titration

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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