Photo-Biocatalysis: Biotransformations in the Presence of Light

Luca Schmermund, Valentina Jurkaš, Fatma Feyza Özgen, Giovanni Davide Barone, Hanna Christiane Büchsenschütz, Christoph K. Winkler, S Schmidt, Robert Kourist, Wolfgang Kroutil

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Light has received increased attention for various chemical reactions but also in combination with biocatalytic reactions. Because currently only a few enzymatic reactions are known, which per se require light, most transformations involving light and a biocatalyst exploit light either for providing the cosubstrate or cofactor in an appropriate redox state for the biotransformation. In selected cases, a promiscuous activity of known enzymes in the presence of light could be induced. In other approaches, light-induced chemical reactions have been combined with a biocatalytic step, or light-induced biocatalytic reactions were combined with chemical reactions in a linear cascade. Finally, enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction. This Review gives an overview of the various approaches for using light in biocatalysis.

Original languageEnglish
Pages (from-to)4115-4144
Number of pages30
JournalACS Catalysis
Volume9
Issue number5
DOIs
Publication statusPublished - 2019

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Chemical reactions
Enzymes
Biotransformation
Biocatalysis
Biocatalysts
Oxidation-Reduction

Keywords

  • biocatalysis
  • biotransformation
  • cascades
  • cofactor recycling
  • photocatalysis

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cooperations

  • NAWI Graz

Cite this

Photo-Biocatalysis: Biotransformations in the Presence of Light. / Schmermund, Luca; Jurkaš, Valentina; Özgen, Fatma Feyza; Barone, Giovanni Davide; Büchsenschütz, Hanna Christiane; Winkler, Christoph K.; Schmidt, S; Kourist, Robert; Kroutil, Wolfgang.

In: ACS Catalysis, Vol. 9, No. 5, 2019, p. 4115-4144.

Research output: Contribution to journalReview articleResearchpeer-review

Schmermund, Luca ; Jurkaš, Valentina ; Özgen, Fatma Feyza ; Barone, Giovanni Davide ; Büchsenschütz, Hanna Christiane ; Winkler, Christoph K. ; Schmidt, S ; Kourist, Robert ; Kroutil, Wolfgang. / Photo-Biocatalysis: Biotransformations in the Presence of Light. In: ACS Catalysis. 2019 ; Vol. 9, No. 5. pp. 4115-4144.
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