Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process

Matthias Wolfgang, Patrick Wahl, Manuel Zettl, Stephan Sacher, Johannes G. Khinast, Rainer Bastian, Thomas Fränkel

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Abstract

This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner.
OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.
Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.
Translated title of the contributionOptische Kohärenz Tomographie (OCT) zur Echtzeit-Analyse der Coating-Variabilität eines kontinuierlichen Coating Prozesses
Original languageEnglish
Publication statusPublished - 17 Nov 2016
EventAIChE Annual Meeting 2016 - Hilton, San Francisco, United States
Duration: 14 Nov 201619 Nov 2016

Conference

ConferenceAIChE Annual Meeting 2016
CountryUnited States
CitySan Francisco
Period14/11/1619/11/16

Fingerprint

tablets
drums
coating
tomography
coatings
sprayers
optical measuring instruments
manufacturing
refractivity
dosage
air

Keywords

  • Optical Coherence Tomography
  • Tablet coating variability
  • Coating layer uniformity
  • Continuous coating process
  • In-line monitoring

Cite this

Wolfgang, M., Wahl, P., Zettl, M., Sacher, S., Khinast, J. G., Bastian, R., & Fränkel , T. (2016). Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process. AIChE Annual Meeting 2016, San Francisco, United States.

Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process. / Wolfgang, Matthias; Wahl, Patrick; Zettl, Manuel; Sacher, Stephan; Khinast, Johannes G.; Bastian, Rainer; Fränkel , Thomas.

2016. AIChE Annual Meeting 2016, San Francisco, United States.

Research output: Contribution to conference(Old data) Lecture or PresentationResearchpeer-review

Wolfgang, M, Wahl, P, Zettl, M, Sacher, S, Khinast, JG, Bastian, R & Fränkel , T 2016, 'Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process' AIChE Annual Meeting 2016, San Francisco, United States, 14/11/16 - 19/11/16, .
Wolfgang, Matthias ; Wahl, Patrick ; Zettl, Manuel ; Sacher, Stephan ; Khinast, Johannes G. ; Bastian, Rainer ; Fränkel , Thomas. / Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process. AIChE Annual Meeting 2016, San Francisco, United States.
@conference{9996308f3e6744818a3e73309684a72d,
title = "Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process",
abstract = "This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner. OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.",
keywords = "Optical Coherence Tomography, Tablet coating variability, Coating layer uniformity, Continuous coating process, In-line monitoring",
author = "Matthias Wolfgang and Patrick Wahl and Manuel Zettl and Stephan Sacher and Khinast, {Johannes G.} and Rainer Bastian and Thomas Fr{\"a}nkel",
year = "2016",
month = "11",
day = "17",
language = "English",
note = "AIChE Annual Meeting 2016 ; Conference date: 14-11-2016 Through 19-11-2016",

}

TY - CONF

T1 - Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process

AU - Wolfgang, Matthias

AU - Wahl, Patrick

AU - Zettl, Manuel

AU - Sacher, Stephan

AU - Khinast, Johannes G.

AU - Bastian, Rainer

AU - Fränkel , Thomas

PY - 2016/11/17

Y1 - 2016/11/17

N2 - This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner. OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.

AB - This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner. OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.

KW - Optical Coherence Tomography

KW - Tablet coating variability

KW - Coating layer uniformity

KW - Continuous coating process

KW - In-line monitoring

M3 - (Old data) Lecture or Presentation

ER -