Abstract
OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.
Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.
| Translated title of the contribution | Optische Kohärenz Tomographie (OCT) zur Echtzeit-Analyse der Coating-Variabilität eines kontinuierlichen Coating Prozesses |
|---|---|
| Original language | English |
| Publication status | Published - 17 Nov 2016 |
| Event | AIChE Annual Meeting 2016 - Hilton, San Francisco, United States Duration: 14 Nov 2016 → 19 Nov 2016 |
Conference
| Conference | AIChE Annual Meeting 2016 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 14/11/16 → 19/11/16 |
Fingerprint
Keywords
- Optical Coherence Tomography
- Tablet coating variability
- Coating layer uniformity
- Continuous coating process
- In-line monitoring
Cite this
Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process. / Wolfgang, Matthias; Wahl, Patrick; Zettl, Manuel; Sacher, Stephan; Khinast, Johannes G.; Bastian, Rainer; Fränkel , Thomas.
2016. AIChE Annual Meeting 2016, San Francisco, United States.Research output: Contribution to conference › (Old data) Lecture or Presentation › Research › peer-review
}
TY - CONF
T1 - Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process
AU - Wolfgang, Matthias
AU - Wahl, Patrick
AU - Zettl, Manuel
AU - Sacher, Stephan
AU - Khinast, Johannes G.
AU - Bastian, Rainer
AU - Fränkel , Thomas
PY - 2016/11/17
Y1 - 2016/11/17
N2 - This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner. OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.
AB - This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner. OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.
KW - Optical Coherence Tomography
KW - Tablet coating variability
KW - Coating layer uniformity
KW - Continuous coating process
KW - In-line monitoring
M3 - (Old data) Lecture or Presentation
ER -