Novel DNA and RNA elements

Julia Pitzer, Bob Van Hove, Aaron M. Love, Parayil Kumaran Ajikumar, Marjan De Mey, Anton Glieder

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Impressive advances in the field of synthetic biology go hand in hand with the discovery, design, and use of novel DNA and RNA elements. Efficient synthesis of large oligonucleotides and double-stranded DNA parts, chip-based synthesis of DNA libraries, and a detailed understanding of fundamental biological mechanisms and increased capacities in bioinformatics enable new findings and applications. In this chapter, reengineered and model-based designed DNA parts such as promoters, terminators, and aptamers, which can be used for controlled gene expression, are discussed. Furthermore, recent advances in the RNA world concerning small RNAs, ribozymes, and riboswitches and novel applications of synthetic nucleotide sequences in the form of DNA walkers and DNA machines are emphasized. The knowledge and experiences gained in the investigations of large numbers of natural and novel DNA and RNA parts have built the foundation for the design of new functions of polynucleotides and model-based regulation of gene and pathway expression.

Original languageEnglish
Title of host publicationSynthetic Biology
Place of PublicationCham
PublisherSpringer International Publishing AG
Pages65-99
Number of pages35
ISBN (Electronic)978-3-319-22708-5
ISBN (Print)978-3-319-22707-8
DOIs
Publication statusPublished - 1 Jan 2015

Fingerprint

RNA
DNA
Riboswitch
Synthetic Biology
Walkers
synthetic biology
polynucleotides
Polynucleotides
Catalytic RNA
synthesis
DNA libraries
Gene Expression Regulation
Bioinformatics
oligonucleotides
Oligonucleotide Array Sequence Analysis
Computational Biology
Gene Library
Oligonucleotides
bioinformatics
Gene expression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Engineering(all)
  • Chemical Engineering(all)

Cite this

Pitzer, J., Van Hove, B., Love, A. M., Ajikumar, P. K., De Mey, M., & Glieder, A. (2015). Novel DNA and RNA elements. In Synthetic Biology (pp. 65-99). Cham: Springer International Publishing AG . https://doi.org/10.1007/978-3-319-22708-5_2

Novel DNA and RNA elements. / Pitzer, Julia; Van Hove, Bob; Love, Aaron M.; Ajikumar, Parayil Kumaran; De Mey, Marjan; Glieder, Anton.

Synthetic Biology. Cham : Springer International Publishing AG , 2015. p. 65-99.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Pitzer, J, Van Hove, B, Love, AM, Ajikumar, PK, De Mey, M & Glieder, A 2015, Novel DNA and RNA elements. in Synthetic Biology. Springer International Publishing AG , Cham, pp. 65-99. https://doi.org/10.1007/978-3-319-22708-5_2
Pitzer J, Van Hove B, Love AM, Ajikumar PK, De Mey M, Glieder A. Novel DNA and RNA elements. In Synthetic Biology. Cham: Springer International Publishing AG . 2015. p. 65-99 https://doi.org/10.1007/978-3-319-22708-5_2
Pitzer, Julia ; Van Hove, Bob ; Love, Aaron M. ; Ajikumar, Parayil Kumaran ; De Mey, Marjan ; Glieder, Anton. / Novel DNA and RNA elements. Synthetic Biology. Cham : Springer International Publishing AG , 2015. pp. 65-99
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