New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins

Herwig Prasch; Cornelia Hojnik; Thisbe K. Lindhorst; Blanka Didak; Ludovic Landemarre; Tanja M. Wrodnigg

doi:10.1016/j.carres.2019.01.010

New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins

Herwig Prasch, Cornelia Hojnik, Thisbe K. Lindhorst, Blanka Didak, Ludovic Landemarre, Tanja M. Wrodnigg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, D-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC₅₀) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Carbohydrate Research
Volume	475
DOIs	https://doi.org/10.1016/j.carres.2019.01.010
Publication status	Published - 1 Mar 2019

Keywords

Amadori rearrangement
Antiadhesives
C-Glycosyl-type glycoconjugates
Carbohydrate-lectin interactions
Inhibition assay

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

Access to Document

10.1016/j.carres.2019.01.010Licence: CC BY 4.0

Cite this

@article{d085259795054e05abe60a79e165de3b,

title = "New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins",

abstract = "1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, D-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.",

keywords = "Amadori rearrangement, Antiadhesives, C-Glycosyl-type glycoconjugates, Carbohydrate-lectin interactions, Inhibition assay",

author = "Herwig Prasch and Cornelia Hojnik and Lindhorst, {Thisbe K.} and Blanka Didak and Ludovic Landemarre and Wrodnigg, {Tanja M.}",

year = "2019",

month = mar,

day = "1",

doi = "10.1016/j.carres.2019.01.010",

language = "English",

volume = "475",

pages = "65--68",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - New lectin ligands

T2 - Testing of Amadori rearrangement products with a series of mannoside-specific lectins

AU - Prasch, Herwig

AU - Hojnik, Cornelia

AU - Lindhorst, Thisbe K.

AU - Didak, Blanka

AU - Landemarre, Ludovic

AU - Wrodnigg, Tanja M.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - 1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, D-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.

AB - 1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, D-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.

KW - Amadori rearrangement

KW - Antiadhesives

KW - C-Glycosyl-type glycoconjugates

KW - Carbohydrate-lectin interactions

KW - Inhibition assay

UR - http://www.scopus.com/inward/record.url?scp=85062416447&partnerID=8YFLogxK

U2 - 10.1016/j.carres.2019.01.010

DO - 10.1016/j.carres.2019.01.010

M3 - Article

C2 - 30844665

AN - SCOPUS:85062416447

SN - 0008-6215

VL - 475

SP - 65

EP - 68

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this