Abstract
A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained N-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was N-alkylated to furnish a set of potential α-galactosidase inhibitors. Their glycosidase inhibitory activities were screened with a panel of standard glycosidases of biological significance.
Original language | English |
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Pages (from-to) | 15943-15951 |
Number of pages | 9 |
Journal | RSC Advances |
Volume | 11 |
Issue number | 26 |
DOIs | |
Publication status | Published - 22 Apr 2021 |
ASJC Scopus subject areas
- Chemical Engineering(all)
- Chemistry(all)