Network plasticity as Bayesian inference

David Kappel, Stefan Habenschuss, Robert Legenstein, Wolfgang Maass

Research output: Contribution to journalArticleResearchpeer-review

Abstract

General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing. We propose that inherently stochastic features of synaptic plasticity and spine motility enable cortical networks of neurons to carry out probabilistic inference by sampling from a posterior distribution of network configurations. This model provides a viable alternative to existing models that propose convergence of parameters to maximum likelihood values. It explains how priors on weight distributions and connection probabilities can be merged optimally with learned experience, how cortical networks can generalize learned information so well to novel experiences, and how they can compensate continuously for unforeseen disturbances of the network. The resulting new theory of network plasticity explains from a functional perspective a number of experimental data on stochastic aspects of synaptic plasticity that previously appeared to be quite puzzling.
Original languageEnglish
Pages (from-to)e1004485-e1004485
JournalPLoS computational biology
Volume11
Issue number11
DOIs
Publication statusPublished - 2015

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Neuronal Plasticity
Bayesian inference
Plasticity
plasticity
Brain
Probabilistic Inference
brain
Spine
Learning
Neurons
Weights and Measures
Statistical Learning Theory
motility
learning
neurons
Motility
Weight Distribution
Maximum likelihood
Posterior distribution
Maximum Likelihood

Fields of Expertise

  • Information, Communication & Computing

Treatment code (Nähere Zuordnung)

  • Theoretical

Cite this

Network plasticity as Bayesian inference. / Kappel, David; Habenschuss, Stefan; Legenstein, Robert; Maass, Wolfgang.

In: PLoS computational biology, Vol. 11, No. 11, 2015, p. e1004485-e1004485.

Research output: Contribution to journalArticleResearchpeer-review

Kappel, David ; Habenschuss, Stefan ; Legenstein, Robert ; Maass, Wolfgang. / Network plasticity as Bayesian inference. In: PLoS computational biology. 2015 ; Vol. 11, No. 11. pp. e1004485-e1004485.
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