Abstract
The purpose of this study was to characterize the heterogeneity of oxygen partial pressure in different adipose tissue zones and to assess the possibility of compensating these heterogeneities during optical glucose measurements. In this proof of concept study, the heterogeneity of oxygen partial pressure was determined in the adipose tissue of a pig by using 48 oxygen sensors in 3 zones of the abdominal region at two different blood oxygen levels. Sensor oxygen values correlated well with reference blood oxygen values and we identified heterogeneities in oxygen partial pressure among the defined zones of the abdominal region. Significant differences in the mean oxygen partial pressure were found when comparing the three abdominal zones but no significant differences were found when comparing two sensors located in close proximity (on one cannula). The low heterogeneity on one cannula allows the compensation of physiological oxygen variations for optical glucose measurements by using an additional oxygen sensor in close proximity to the glucose sensor. In addition, this setup can be used to continuously monitor tissue oxygenation e.g. in patients with adipose tissue dysfunction or serve limb ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 583-586 |
| Number of pages | 4 |
| Journal | Journal of Clinical Monitoring and Computing |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jun 2018 |
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Keywords
- Optical glucose measurement
- Optical oxygen sensor
- Oxygen distribution
- Tissue monitoring
ASJC Scopus subject areas
- Health Informatics
- Critical Care and Intensive Care Medicine
- Anesthesiology and Pain Medicine
Cite this
Monitoring tissue oxygen heterogeneities and their influence on optical glucose measurements in an animal model. / Rumpler, M.; Hajnsek, M.; Baumann, P.; Pieber, T. R.; Klimant, I.
In: Journal of Clinical Monitoring and Computing, Vol. 32, No. 3, 01.06.2018, p. 583-586.Research output: Contribution to journal › Letter › Research › peer-review
}
TY - JOUR
T1 - Monitoring tissue oxygen heterogeneities and their influence on optical glucose measurements in an animal model
AU - Rumpler, M.
AU - Hajnsek, M.
AU - Baumann, P.
AU - Pieber, T. R.
AU - Klimant, I.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The purpose of this study was to characterize the heterogeneity of oxygen partial pressure in different adipose tissue zones and to assess the possibility of compensating these heterogeneities during optical glucose measurements. In this proof of concept study, the heterogeneity of oxygen partial pressure was determined in the adipose tissue of a pig by using 48 oxygen sensors in 3 zones of the abdominal region at two different blood oxygen levels. Sensor oxygen values correlated well with reference blood oxygen values and we identified heterogeneities in oxygen partial pressure among the defined zones of the abdominal region. Significant differences in the mean oxygen partial pressure were found when comparing the three abdominal zones but no significant differences were found when comparing two sensors located in close proximity (on one cannula). The low heterogeneity on one cannula allows the compensation of physiological oxygen variations for optical glucose measurements by using an additional oxygen sensor in close proximity to the glucose sensor. In addition, this setup can be used to continuously monitor tissue oxygenation e.g. in patients with adipose tissue dysfunction or serve limb ischemia.
AB - The purpose of this study was to characterize the heterogeneity of oxygen partial pressure in different adipose tissue zones and to assess the possibility of compensating these heterogeneities during optical glucose measurements. In this proof of concept study, the heterogeneity of oxygen partial pressure was determined in the adipose tissue of a pig by using 48 oxygen sensors in 3 zones of the abdominal region at two different blood oxygen levels. Sensor oxygen values correlated well with reference blood oxygen values and we identified heterogeneities in oxygen partial pressure among the defined zones of the abdominal region. Significant differences in the mean oxygen partial pressure were found when comparing the three abdominal zones but no significant differences were found when comparing two sensors located in close proximity (on one cannula). The low heterogeneity on one cannula allows the compensation of physiological oxygen variations for optical glucose measurements by using an additional oxygen sensor in close proximity to the glucose sensor. In addition, this setup can be used to continuously monitor tissue oxygenation e.g. in patients with adipose tissue dysfunction or serve limb ischemia.
KW - Optical glucose measurement
KW - Optical oxygen sensor
KW - Oxygen distribution
KW - Tissue monitoring
UR - http://www.scopus.com/inward/record.url?scp=85020263891&partnerID=8YFLogxK
U2 - 10.1007/s10877-017-0034-y
DO - 10.1007/s10877-017-0034-y
M3 - Letter
VL - 32
SP - 583
EP - 586
JO - Journal of Clinical Monitoring and Computing
JF - Journal of Clinical Monitoring and Computing
SN - 1387-1307
IS - 3
ER -